Pulmonary Disease (COPD), Chronic Obstructive Clinical Trial
Official title:
Respiratory Microbiome in COPD. Relationship With Systemic and Pulmonary Inmune Response.
Hypothesis:
COPD patients with frequent exacerbations have different pulmonary and systemic immune
response than COPD patients without frequent exacerbations and this is related to their
microbiome.
The objective of this project is to determine the pulmonary microbiome and its relationship
with the pulmonary and systemic inmune response in COPD patients with frequent (FE) and non
frequent exacerbations (NE).
1. The pulmonary immune response.
-The role of mucins, antimicrobial peptides (AMPs), Matrix metalloproteinases (MMPs) and
Toll-like receptors (TLRs) as lung defense mechanisms and their possible relationship
with the microbiome in COPD and FE patients.
2. The systemic immune response. -The pulmonary and blood inflammatory response and
circulating bacterial products as markers of the systemic immune response.
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