Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Dynamic Changes of the Respiratory Microbiota and Its Relationship to Fecal Microbiota in Chronic Obstructive Pulmonary Disease
Patients with chronic obstructive pulmonary disease (COPD) are 2-3 times more likely to occur
together with chronic gastrointestinal tract (GIT) diseases, such as inflammatory bowel
disease (IBD) or irritable bowel syndrome (IBS). Similarly, despite many patients have no
history of acute or chronic respiratory disease, up to 50% of IBD patients and 33% of IBS
patients have pulmonary involvement, such as inflammation or impaired lung function.
Increasing evidence indicated chronic gut and lung disease share key conceptual features with
the disorder and dysregulation of the microbial ecosystem. However, the underlying mechanisms
are not well understood.
Our study is aimed to elucidate the intimate relationship between the gastrointestinal tract
and respiratory tract, and uncover the mechanisms by which the gut microbiota affects the
immune responses in the lungs, and vice versa.
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