Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Daily Supplementation of Magnesium Citrate in Moderate-severe Chronic Obstructive Pulmonary Disease: a Randomized, Controlled, Double-blind Trial
Magnesium (Mg) is involved in several pathways that could be affected in chronic obstructive
pulmonary diseases (COPDs), namely in the contractility and excitability of neuro-muscolar
endothelial cells and low-grade inflammation, a typical state of COPD. In this sense,
several randomized controlled trials (RCTs) confirmed a positive role of Mg in asthma since
long-period oral supplementation of Mg leads to a clinical and spirometric improvement.
Subjects with COPD seem to have a reduced bioavailability of Mg probably due to the use of
drugs that may increase Mg losses (e.g. beta-agonists and cortisones), to a reduced dietary
Mg intake, and heavy smoking. A recent study showed that the administration of endovenous or
aerosol Mg sulphate with beta-agonists acutely improve maximum expiratory flow during COPD
relapses as well as the prolonged treatment with endovenous sulphate Mg led to a reduction
in pulmonary hyperinflation and increase in muscles involved in respiration, with a
consequent clinical and instrumental improvement.
These evidences suggest that a chronic supplementation with Mg could improve COPD in
clinical and instrumental parameters, but, at the best of our knowledge, no study was
available in this sense.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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