Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
A Dangerous Triad in Ageing and in COPD - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition
The investigators have taken part in the development of simple muscle function tests and
studied physical training and energy turnover in patients with chronic obstructive pulmonary
disease, COPD. The investigators have found that muscle wasting in COPD is related to poor
prognosis and that physical training might lead to improved, less energy-demanding muscle
function. Elderly subjects also suffer from muscle wasting that leads to frailty, poor
autonomy and, secondarily, fractures. In the planned study the investigators will validate
simple muscle function tests (hand grip strength, heel rise test, voluntary quadriceps
muscle strength, 30 m walking test and balance tests) in both groups by relating them to an
involuntary, magnet stimulated, test of quadriceps force, HRQL, tests of body composition
(impedance, DXA) and recordings of physical activity. The relation between food intake,
systemic inflammation, muscle mass and function will be analysed.
The study has been ethically approved and started in COPD patients and will be expanded to a
representative sample of elderly.
Simple, evaluated muscle function tests applied in primary care may be used for early
detection of muscle dysfunction in COPD patients and elderly so that early intervention
against impaired muscle function can be started. Analyses of food intake and of inflammatory
markers might identify factors of special importance for muscle dysfunction, which
eventually might lead to improved dietary therapy and pharmacological interventions.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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