Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Lung Transplant for COPD: Outcomes/Technology
Most people undergoing lung transplantation have chronic obstructive pulmonary disease (COPD), a disease in which the lung airways are partly damaged and obstructed, making it difficult to breathe. This study will enroll people with COPD who are undergoing a lung transplant to examine how their quality of life changes after the transplant procedure.
Lung transplantation is one treatment option for people with end-stage lung disease. The
majority of people undergoing a lung transplant have COPD, and while transplantation can
potentially improve survival and quality of life, it may also carry substantial risks,
including surgical complications, infections, and pneumonia. The impact of lung
transplantation on survival and quality of life has not been extensively studied. In the
United States, the United Network for Organ Sharing (UNOS) is the organization that allocates
donor lungs to lung recipients. Before 2005, the length of time that a candidate had been on
the transplant waiting list was the major determining factor for receiving a donor lung. In
mid 2005, the UNOS system changed and began prioritizing candidates on the basis of risk of
death prior to lung transplantation and the probability of death within the first year after
transplantation. The purpose of this study is to evaluate quality of life factors for lung
transplant patients with COPD, both before and after the lung transplant procedure. In
addition, quality of life of patients in the new UNOS allocation system will be compared with
that of patients in the old UNOS allocation system.
This study will enroll all COPD patients undergoing an evaluation for lung transplantation at
the Washington University Medical Center and Barnes-Jewish Hospital in St. Louis, Missouri.
Participants will attend study visits at the time of the transplant evaluation and again just
prior to listing in the UNOS system. After the transplant, participants will attend study
visits at Months 3 and 6 and then once a year for 5 years. During each study visit,
participants will complete a computerized interview and health-related questionnaires that
will assess quality of life factors, including social life, work life, and home life. Study
researchers will also review participants' medical records to collect information on lung
function and blood test results.
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