Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension

Pulmonary Artery Hypertension Clinical Trial

Official title:

Evaluation of Primary and Accessory Respiratory Muscles and Their Influence on Exercise Capacity and Dyspnea in Pulmonary Arterial Hypertension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05056532
• Other study ID #: PAH
• Status: Completed
• Start date: September 9, 2021
• Est. completion date: April 18, 2022

Study information

• Verified date: May 2022
• Source: Giresun University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)

Recruitment information / eligibility

• Status: Completed
• Enrollment: 52
• Est. completion date: April 18, 2022
• Est. primary completion date: March 28, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

• patients with diagnosis of pulmonary arterial hypertension

• patients with stabil drug therapy at least three months

Exclusion Criteria:

• patients with obstructive and/ or restrictive lung disease comorbidity

• severe orthopedic and/ or neurological comorbidity

• patients with heart failure

• patients with ischemic heart disease

• uncooperative patients

Related Conditions & MeSH terms

• Hypertension
• Pulmonary Arterial Hypertension
• Pulmonary Artery Hypertension

Intervention

Diagnostic Test:
• patient assessment
subjective and objective measurement will be performed in patients with PAH

Locations

Country	Name	City	State
Turkey	Istanbul university-cerrahpasa cardiology institute	Istanbul	Haseki

Sponsors (1)

Lead Sponsor	Collaborator
Giresun University

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Panagiotou M, Peacock AJ, Johnson MK. Respiratory and limb muscle dysfunction in pulmonary arterial hypertension: a role for exercise training? Pulm Circ. 2015 Sep;5(3):424-34. doi: 10.1086/682431. Review. — View Citation

Riou M, Pizzimenti M, Enache I, Charloux A, Canuet M, Andres E, Talha S, Meyer A, Geny B. Skeletal and Respiratory Muscle Dysfunctions in Pulmonary Arterial Hypertension. J Clin Med. 2020 Feb 3;9(2). pii: E410. doi: 10.3390/jcm9020410. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pectoralis muscle strength	pectoralis muscle strength will be evaluated with hand held dynamometers according to muscle test technique	15 minute
Primary	serratus anterior muscle strength	Serratus anterior muscle strength will be evaluated with hand held dynamometers according to muscle test technique	15 minutes
Primary	sternocleidomasteoideus muscle strength	sternocleidomasteoideus muscle strength will be evaluated with hand held dynamometers according to muscle test technique	15 minutes
Primary	Respiratory mouth pressure	Respiratory mouth pressure will be measured to determine maximally inspiratory pressure and maximally expiratory pressure according to ATS/ERS guidelines.	15 minutes
Secondary	Six Minute Walk Test (6MWT)	Six minute walk test will be performed to evalute functionally exercise capacity according to ATS/ERS guidelines	30 minutes
Secondary	Dyspnea assessment	London Chest Activity of Daily Living Scale will be used to sensation of dyspnea during activity of daily living.The scale consists of four domains: self-care (four items), domestic (six items), physical (two items) and leisure (three items). In total, the scale consisting of 15 items scored of 0 to 5. 0 means that "I wouldn't do anyway" and 5 means that "Someone else does it for me". Higher values indicate greater limitation due to the dyspnea	20 minutes