Kisspeptin/GPR54 Pathway and Early Puberty

Puberty, Precocious Clinical Trial

Official title:

Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04012632
• Other study ID #: szCDC_1
• Status: Completed
• Start date: September 1, 2016
• Est. completion date: July 4, 2019

Study information

• Verified date: July 2019
• Source: Shenzhen Center for Disease Control and Prevention
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 628
• Est. completion date: July 4, 2019
• Est. primary completion date: May 20, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 7 Years to 10 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria:

• The participants who were not the first visit to the hospital and had been treated before.

• The participants who were with endocrine disorders.

Related Conditions & MeSH terms

• Puberty, Precocious

Intervention

Other:
• this study was an observational study and no interventions were given to the participants
the participants were recruited and the data as well as blood sample were collected.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Shenzhen Center for Disease Control and Prevention

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the polymorphism in the KISS1/GPR54 pathway genes	functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.	3 months