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Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder

PTSD Clinical Trial

Official title:
Randomized Controlled Trial of Glecaprevir/Pibrentasvir for the Treatment of Post-traumatic Stress Disorder

Clinical Trial Summary

A double-blind randomized placebo-controlled trial to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV).

Clinical Trial Description

N=92 patients with posttraumatic stress disorder (PTSD) will be enrolled into a double-blind randomized placebo-controlled trial to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with PTSD symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV). The research is intended to test the efficacy of GLE/PIB for PTSD symptom improvement in the absence of HCV. Primary Aims: Aim 1: Determine the efficacy of GLE/PIB for PTSD symptom improvement. Aim 2: Determine the efficacy of GLE/PIB for functioning improvement among patients with PTSD. Aim 3: Assess the safety and tolerability of GLE/PIB treatment for patients with PTSD in the absence of HCV. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05637879
Study type Interventional
Source White River Junction Veterans Affairs Medical Center
Contact Bradley V Watts, MD, MPH
Phone 802-295-9363
Email bradley.watts@va.gov
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date July 1, 2023
Completion date September 30, 2026
View Details
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