PTSD Clinical Trial - Improving Therapeutic Learning for PTSD

Status Recruiting

Clinical Trial Summary

The proposed project seeks to demonstrate the engagement of post-exposure dopamine neurotransmission and downstream acute reorganization of dopaminergic resting-state neural networks as a means of increasing consolidation of extinction memories formed during analogue exposure therapy in adult women with PTSD. Participants will include 120 women aged 21-50 with a current diagnosis of PTSD related to physical or sexual assault, English speaking, and medically healthy. Participants will complete the stages of the study across 2-3 days, depending on participant need.

Clinical Trial Description

Specific Aim 1: Test the degree to which exogeneous manipulations of dopamine neurotransmission affect exposure therapy learning across multiple indices. Hypothesis: L-DOPA will decrease measures of fear responding across indices. Specific Aim 2: Test the degree to which post-exposure functional connectivity within dopaminergic neural networks mediates the effect of dopaminergic manipulation on fear responding after exposure therapy. Hypothesis: L-DOPA will predict enhanced post-exposure dopaminergic functional connectivity, which in turn predicts decrease fear recall. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04558112
Study type	Interventional
Source	University of Wisconsin, Madison
Contact	Chloe Botsford
Phone	608-262-6375
Email	cbotsford@wisc.edu
Status	Recruiting
Phase	Phase 2
Start date	February 18, 2021
Completion date	December 2023

View Details

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