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Quetiapine Treatment for Post-Traumatic Stress Disorder (PTSD) — PTSD  

PTSD Clinical Trial

Official title:
A Randomized, Placebo-Controlled Trial of Quetiapine (Seroquel) Monotherapy in the Treatment of PTSD

Clinical Trial Summary

The purpose of the study is to determine if quetiapine is effective in the treatment of PTSD.

Clinical Trial Description

Objective: To assess the impact of quetiapine on core PTSD symptoms and associated psychiatric comorbidity including depressive and positive and negative psychotic symptoms.

Research Design: 12-week, double-blind, placebo-controlled, randomized, fixed-flexible dose trial of quetiapine monotherapy.

Intervention: Eligible patients will be randomized to receive quetiapine starting at 25 mg daily or matching placebo. Dose adjustments (to a minimum of 50 mg or a maximum of 800 mg), will be made at the investigator's discretion and according to patient's clinical response. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00237393
Study type Interventional
Source Ralph H. Johnson VA Medical Center
Contact
Status Completed
Phase Phase 4
Start date August 2003
Completion date December 2007
View Details
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