Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis

Psychotic Disorders Clinical Trial

— ANTE-UP  

Official title:

A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05686772
• Other study ID #: 2020-OJUR-286304
• Status: Recruiting
• Start date: November 1, 2019
• Est. completion date: May 1, 2024

Study information

• Verified date: January 2023
• Source: Laval University
• Contact: Olivier Corbeil, PharmD, MSc
• Phone: 1-418-663-5000
• Email: olivier.corbeil.1[@]ulaval.ca
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this observational study is to get a better understanding of the association between problem gambling psychotic disorders among young adults with firs-episode psychosis. The main questions to be answered are: 1. What are the incidence and risk factors for problem gambling in this population? 2. How effective are the current treatments for problem gambling in adults with first-episode psychosis? To do so, comparisons will be made among the study cohort for various factors: - Use of dopamine partial agonists; - Psychiatric comorbidities; - Socioeconomic status; - Sex; - Gender; - Gambling history. The nature of the treatments for problem gambling offered and received by the subjects, as well as their effectiveness, will also be documented.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 800
• Est. completion date: May 1, 2024
• Est. primary completion date: May 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• 18 to 35 years old;
• Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features).

Exclusion Criteria:

• DSM-5 diagnosis of psychotic disorder due to a medical condition;
• Severe intellectual disability.

Related Conditions & MeSH terms

• Disease
• Gambling
• Gambling Disorder
• Mental Disorders
• Psychotic Disorders

Intervention

Drug:
• Dopamine partial agonists
Use of antipsychotics (i.e., dopamine partial agonists vs dopamine antagonists)

Other:
• Psychiatric comorbidities
Mainly substance use disorders and personality disorders
• Sex
Biological sex at birth
• Gender
Current gender identity
• Socioeconomic status
Including main source of income, employment status, homelessness
• Gambling history
History of gambling (i.e., recreational or problematic) prior to admission in the clinics

Locations

Country	Name	City	State
Canada	Montreal University Hospital Center	Montreal	Quebec
Canada	Quebec Mental Health University Institute	Quebec

Sponsors (2)

Lead Sponsor	Collaborator
Laval University	Fonds de recherche du Québec

Country where clinical trial is conducted

Canada, 

References & Publications (6)

Bergamini A, Turrina C, Bettini F, Toccagni A, Valsecchi P, Sacchetti E, Vita A. At-risk gambling in patients with severe mental illness: Prevalence and associated features. J Behav Addict. 2018 Jun 1;7(2):348-354. doi: 10.1556/2006.7.2018.47. Epub 2018 Jun 5. — View Citation

Corbeil O, Corbeil S, Dorval M, Carmichael PH, Giroux I, Jacques C, Demers MF, Roy MA. Problem Gambling Associated with Aripiprazole: A Nested Case-Control Study in a First-Episode Psychosis Program. CNS Drugs. 2021 Apr;35(4):461-468. doi: 10.1007/s40263-021-00801-4. Epub 2021 Mar 13. — View Citation

Corbeil O, Corbeil S, Giroux I, Jacques C, Dorval M, Demers MF, Roy MA. Problem Gambling Associated With Aripiprazole in First-Episode Psychosis Patients: A Series of 6 Case Reports. J Clin Psychopharmacol. 2020 Mar/Apr;40(2):191-194. doi: 10.1097/JCP.0000000000001177. — View Citation

Desai RA, Potenza MN. A cross-sectional study of problem and pathological gambling in patients with schizophrenia/schizoaffective disorder. J Clin Psychiatry. 2009 Sep;70(9):1250-7. doi: 10.4088/JCP.08m04359. Epub 2009 Jun 16. — View Citation

Haydock M, Cowlishaw S, Harvey C, Castle D. Prevalence and correlates of problem gambling in people with psychotic disorders. Compr Psychiatry. 2015 Apr;58:122-9. doi: 10.1016/j.comppsych.2015.01.003. Epub 2015 Jan 15. — View Citation

Lachance A, Corbeil O, Corbeil S, Chalifour G, Breault AS, Roy MA, Demers MF. Case Reports of Aripiprazole and Problematic Gambling in Schizophrenia: A Critical Review of the Evidence. J Clin Psychopharmacol. 2019 Jul/Aug;39(4):393-397. doi: 10.1097/JCP.0000000000001068. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At baseline (i.e., at admission in the clinic)
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At 6 months
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At 12 months
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At 18 months
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At 24 months
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At 30 months
Primary	Gambling disorder	Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist	At 36 months
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At baseline (i.e., at admission in the clinic)
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At 6 months
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At 12 months
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At 18 months
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At 24 months
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At 30 months
Secondary	Problem gambling	Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager	At 36 months