Psychotic Disorders Clinical Trial
— ANTE-UPOfficial title:
A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery
The aim of this observational study is to get a better understanding of the association between problem gambling psychotic disorders among young adults with firs-episode psychosis. The main questions to be answered are: 1. What are the incidence and risk factors for problem gambling in this population? 2. How effective are the current treatments for problem gambling in adults with first-episode psychosis? To do so, comparisons will be made among the study cohort for various factors: - Use of dopamine partial agonists; - Psychiatric comorbidities; - Socioeconomic status; - Sex; - Gender; - Gambling history. The nature of the treatments for problem gambling offered and received by the subjects, as well as their effectiveness, will also be documented.
Status | Recruiting |
Enrollment | 800 |
Est. completion date | May 1, 2024 |
Est. primary completion date | May 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - 18 to 35 years old; - Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features). Exclusion Criteria: - DSM-5 diagnosis of psychotic disorder due to a medical condition; - Severe intellectual disability. |
Country | Name | City | State |
---|---|---|---|
Canada | Montreal University Hospital Center | Montreal | Quebec |
Canada | Quebec Mental Health University Institute | Quebec |
Lead Sponsor | Collaborator |
---|---|
Laval University | Fonds de recherche du Québec |
Canada,
Bergamini A, Turrina C, Bettini F, Toccagni A, Valsecchi P, Sacchetti E, Vita A. At-risk gambling in patients with severe mental illness: Prevalence and associated features. J Behav Addict. 2018 Jun 1;7(2):348-354. doi: 10.1556/2006.7.2018.47. Epub 2018 Jun 5. — View Citation
Corbeil O, Corbeil S, Dorval M, Carmichael PH, Giroux I, Jacques C, Demers MF, Roy MA. Problem Gambling Associated with Aripiprazole: A Nested Case-Control Study in a First-Episode Psychosis Program. CNS Drugs. 2021 Apr;35(4):461-468. doi: 10.1007/s40263-021-00801-4. Epub 2021 Mar 13. — View Citation
Corbeil O, Corbeil S, Giroux I, Jacques C, Dorval M, Demers MF, Roy MA. Problem Gambling Associated With Aripiprazole in First-Episode Psychosis Patients: A Series of 6 Case Reports. J Clin Psychopharmacol. 2020 Mar/Apr;40(2):191-194. doi: 10.1097/JCP.0000000000001177. — View Citation
Desai RA, Potenza MN. A cross-sectional study of problem and pathological gambling in patients with schizophrenia/schizoaffective disorder. J Clin Psychiatry. 2009 Sep;70(9):1250-7. doi: 10.4088/JCP.08m04359. Epub 2009 Jun 16. — View Citation
Haydock M, Cowlishaw S, Harvey C, Castle D. Prevalence and correlates of problem gambling in people with psychotic disorders. Compr Psychiatry. 2015 Apr;58:122-9. doi: 10.1016/j.comppsych.2015.01.003. Epub 2015 Jan 15. — View Citation
Lachance A, Corbeil O, Corbeil S, Chalifour G, Breault AS, Roy MA, Demers MF. Case Reports of Aripiprazole and Problematic Gambling in Schizophrenia: A Critical Review of the Evidence. J Clin Psychopharmacol. 2019 Jul/Aug;39(4):393-397. doi: 10.1097/JCP.0000000000001068. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At baseline (i.e., at admission in the clinic) | |
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 6 months | |
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 12 months | |
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 18 months | |
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 24 months | |
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 30 months | |
Primary | Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 36 months | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At baseline (i.e., at admission in the clinic) | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 6 months | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 12 months | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 18 months | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 24 months | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 30 months | |
Secondary | Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 36 months |
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