Exercise and Overnight Motor Sequence Task

Psychotic Disorders Clinical Trial

— EOMST  

Official title:

12-week Aerobic-Anaerobic Transition Exercise Intervention and Overnight Sleep-dependent Procedural Memory Consolidation in Patients With Schizophrenia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03800368
• Other study ID #: HKU_Psych
• Status: Completed
• Phase: N/A
• Start date: December 21, 2016
• Est. completion date: September 1, 2017

Study information

• Verified date: January 2019
• Source: The University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 51
• Est. completion date: September 1, 2017
• Est. primary completion date: September 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Aged from 18 to 55

• Based on the SCID diagnosed to have schizophrenia and related psychotic disorders

• Ability to understand the nature of the study and to give written informed consent

Exclusion Criteria:

• Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders

• Comorbid substance dependence

• Unstable psychotic symptoms

• A history of brain trauma or organic brain disease

• Known history of intellectual disability or special school attendance

• Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

Related Conditions & MeSH terms

• Disease
• Mental Disorders
• Psychotic Disorders
• Schizophrenia
• Schizophrenia and Related Disorders

Intervention

Other:
• Exercise
Indoor cycling exercise intervention
• Non-exercise
Psycho-education

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The sleep-dependent procedural memory consolidation after 12 weeks of intervention	Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment.	12-week Follow-up
Secondary	The verbal memory consolidation after 12 weeks of intervention	Tested by comparing the logical memory task performance between the three groups during the 12-week follow-up assessment	12-week Follow-up
Secondary	The attention performance after 12 weeks of intervention	Measured by using the cancellation task performance and compare between the three groups during the 12-week follow-up assessment	12-week Follow-up
Secondary	The sleep quality after 12 weeks of intervention	Measured by using the Pittsburgh Sleep Quality Index (PSQI) and compare the differences between the three groups during the 12-week follow-up assessment	12-week Follow-up
Secondary	The insomnia severity after 12 weeks of intervention	Measured by using the Insomnia Severity Index (ISI) and compare the differences between the three groups during the 12-week follow-up assessment	12-week Follow-up