A Comparison of Cognitive Training Approaches in Psychotic Disorders

Psychotic Disorders Clinical Trial

Official title:

A Comparison of Cognitive Training Approaches in Psychotic Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03024203
• Other study ID #: PSYC-173-16
• Status: Completed
• Phase: N/A
• Start date: August 2016
• Est. completion date: March 2018

Study information

• Verified date: November 2018
• Source: Queen's University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: March 2018
• Est. primary completion date: March 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• psychotic disorder

• No previous cognitive remediation in past 6 months

Exclusion Criteria:

• Brain injury

• Substance abuse

• Neurocognitive disorder

• Developmental Disability

Related Conditions & MeSH terms

• Disease
• Mental Disorders
• Psychotic Disorders

Intervention

Behavioral:
• Cognitive Remediation - Executive Training
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.
• Cognitive Remediation - Perceptual Training
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.

Locations

Country	Name	City	State
Canada	Queen's University	Kingston	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Queen's University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline	Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks	Post-treatment (within 2 weeks following the end of treatment)
Secondary	Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline	The MCCB is the gold standard cognitive assessment for schizophrenia research	Post-treatment (within 2 weeks following the end of treatment)
Secondary	Change in Neurophysiology - EEG from Baseline	Alpha and Theta band synchronization, p300, mismatch negativity	Post-treatment (within 2 weeks following the end of treatment)
Secondary	Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline	Performance based measure of real life functional skills using role-play	Post-treatment (within 2 weeks following the end of treatment)
Secondary	Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline	Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks	Follow-Up (3 months after the end of treatment)
Secondary	Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline	The MCCB is the gold standard cognitive assessment for schizophrenia research	Follow-Up (3 months after the end of treatment)
Secondary	Change in Neurophysiology - EEG from Baseline	Alpha and Theta band synchronization, p300, mismatch negativity	Follow-Up (3 months after the end of treatment)
Secondary	Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline	Performance based measure of real life functional skills using role-play	Follow-Up (3 months after the end of treatment)