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Effects of GLYX-13 on Learning and Memory in Healthy Individuals and Those With Psychiatric Illness

Healthy Clinical Trial

Official title:
Functional Neuroimaging Effects of the N-methyl-D-aspartate Receptor (NMDAR) Partial Agonist, GLYX-13, on Learning and Memory in Healthy Individuals

Clinical Trial Summary

The present study proposes to evaluate the potential cognitive enhancing effects of GLYX-13, an NMDAR partial agonist, among a group of healthy adults and those with psychiatric illness on a series of functional magnetic resonance imaging (fMRI) learning and memory tasks.

Clinical Trial Description

In a single blind randomized parallel group design, we will evaluate the whether a single dose of GLYX-13 vs. placebo increases cognitive performance on tasks of learning, declarative memory, and working memory, and associated task-related increases in blood oxygen level-dependent (BOLD) activation in hippocampus and dorsolateral prefrontal cortex, respectively. Positive findings will provide biomarker evidence for GLYX-13 effects on neural systems underlying these cognitive processes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01844726
Study type Interventional
Source Northwestern University
Contact
Status Terminated
Phase Phase 2
Start date May 2013
Completion date January 2016
View Details
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