Psoriasis Clinical Trial
Official title:
The Efficacy of Low-Dose Enoxaparin in Psoriasis
Rationale: - Psoriasis is a chronic immune-mediated inflammatory skin disorder where T cells play a fundamental role in its pathogenesis. - Low molecular weight heparin has been reported to exert immunomodulatory effect at small doses through inhibition of T cells heparinase enzyme. - Low molecular weight heparin may have promising results for treatment of psoriasis. Research question: - Can low molecular weight heparin be used safely for treatment of psoriasis with good outcome? - Is enoxaparin inhibitory effect on T cell heparinase enzyme responsible for its beneficial effect? Hypothesis: - Low molecular weight heparin can achieve good results when used at small doses for treatment of psoriasis. - Heparin can exert immunomodulatory effect in psoriasis through inhibition of T cell heparinase enzyme. AIM OF WORK -The aim of this work is to assess the possible clinical efficacy and safety of low-dose enoxaparin in the treatment of psoriasis and to detect if inhibition of heparinase enzyme might account for its beneficial therapeutic effect. Objectives: - To evaluate safety and efficacy of low molecular weight heparin at small dose for treatment of psoriasis. - Contribute to the ongoing efforts to optimize psoriasis management and improve the lives of individuals affected by this chronic condition.
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