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Clinical Trial Summary

combination deucravacitinib and enstilar foam


Clinical Trial Description

30 adult patients with moderate to severe plaque psoriasis will be given Deucravacitinib 6mg QD for the first 8 weeks of the study. At week 8: Subjects who do not meet PASI 25 at week 8 will be discontinued from the study as non-responders. Subjects who achieve ≥PASI 75 at week 8 will remain enrolled and continue Deucravacitinib 6mg QD monotherapy through week 24. Subjects who achieved between PASI 25-74 response will receive 4 weeks of Enstilar (calcipotriene and betamethasone dipropionate) Foam, 0.005%/0.064% applied QD in addition to continuing Deucravacitinib 6mg QD. At week 12, (after 4 consecutive weeks of Enstilar), subjects in the PASI 25-74 group, will discontinue Enstilar QD and continue Deucravacitinib as monotherapy through week 24. Subjects will return at week 28 for safety follow evaluation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06329258
Study type Interventional
Source Psoriasis Treatment Center of Central New Jersey
Contact
Status Completed
Phase Phase 4
Start date December 6, 2022
Completion date November 13, 2023

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