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NCT05401006 Clinical Trial

Effect of Acitretin Versus Narrowband Ultraviolet B on Neopterin Level in Psoriatic Patients .

Psoriasis Clinical Trial

Official title:
Evaluation of the Effect of Acitretin Versus Narrowband Ultraviolet B on Serum Neopterin Level in Psoriatic Patients .

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT05401006
Other study ID # 209/6/21
Secondary ID
Status Active, not recruiting
Phase Phase 4
First received
Last updated
Start date June 5, 2021
Est. completion date June 5, 2023

Study information
Verified date May 2022
Source South Valley University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 30
Est. completion date June 5, 2023
Est. primary completion date June 5, 2022
Accepts healthy volunteers No
Gender All
Age group 15 Years to 60 Years
Eligibility Inclusion Criteria: - Patients with psoriasis diagnosed clinically Aged (15-60). Exclusion Criteria: - Patient with history of skin cancer. - Patient with history of photosensitivity. - Pregnancy and lactation. - Liver failure. - Renal failure. - Patient with psoriatic artheritis. - Patient with allergy to product or any of its components. - Patient with poorly controlled dyslipidemia. - Patient receiving tetracyclines.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Acitretin 25Mg Cap
Acitretin is an oral retinoid (a derivative of vitamin A) given in a dose 0.25-1 mg /kg/day for 3months in psoriatic patients
Radiation:
• Narrowband ultraviolet B
Narrowband UVB is the most common form of phototherapy used to treat psoriasis, given 2-3 sessions per week for 3 successive months

Locations
Country Name City State
Egypt South Valley University Qina

Sponsors (1)
Lead Sponsor Collaborator
South Valley University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Serum Neopterin in psoriasis Measurement of Neopterin in psoriatic patients before and after treatment with NB-UVB, Acitretin and combination of both modalities using ELISA (enzyme-linked immunosorbent assay). 3 Months
Secondary Treatment of psoriasis Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB, Acitretin and combination of both modalities. 3 Months
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