Psoriasis Clinical Trial
Official title:
Use of Serum Mac-2 Binding Protein and Musculoskeletal Ultrasound to Predict Arthritis in Psoriatic Patients
Aims of the study:
1. Measurement of serum level of Mac 2 binding protein among patients with psoriasis,
psoriatic arthritis and subclinical psoriatic arthritis compared with healthy
individuals.
2. Evaluation of MSUS findings in patients with PsA and subclinical psoriatic arthritis
3. Evaluation of the role of serum level of Mac 2 binding protein and MSUS in predicting
arthritis among psoriatic patients.
Psoriasis is a quite common chronic, inflammatory immune-mediated skin disease affecting
about 2% of the population . Also psoriasis is a strong risk factor for the development of
several comorbidities of which the most common is psoriatic arthritis (PsA).
The presence of cutaneous psoriasis indicates a high risk for developing PsA. Studies
conducted in dermatology clinics have shown a high prevalence of undiagnosed PsA in psoriasis
patients , therefore identifying soluble biomarkers for PsA in psoriasis patients may help in
early diagnosis, and thereby prevent disability and improve quality of life .
Mac 2 binding protein [M2BP] is thought to be a marker of synovial cell activation and joint
destruction .M2BP may be involved in the pathogenesis of PsA .
Recently, with the introduction of new medications and wider use of musculoskeletal
ultrasound (US) imaging in clinical practice, the possibility of earlier US diagnosis in
patients with psoriasis in the pre-clinical phase of PsA has been examined.
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