Psoriasis Clinical Trial
— TARGET-DERMOfficial title:
A Longitudinal Observational Study of Patients Undergoing Therapy for Immune-Mediated Inflammatory Skin Conditions
TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice. TARGET-DERM will create a research registry of patients with IMISC within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.
Status | Recruiting |
Enrollment | 15000 |
Est. completion date | December 2050 |
Est. primary completion date | December 2050 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - 1. Adults and children (all ages) with Atopic Dermatitis or other Immune-mediated Inflammatory Skin Conditions been prescribed any dermatologic treatment. - 2. Participant has plans for future visits at the site for continued management of IMISC. Exclusion Criteria: - 1. Inability to provide written informed consent/assent. - 2. Subjects participating in any interventional study or trial for IMISC treatment trial at the time of enrollment. Patients may be enrolled in TARGET-DERM once participation in the trial is complete. Note: Participants may be enrolled in other registries or studies where IMISC treatment outcomes are observed and/or reported (such as center-based registries). |
Country | Name | City | State |
---|---|---|---|
Canada | Innovaderm Research, Inc. | Montréal | Quebec |
Canada | Skin Centre for Dermatology | Peterborough | Ontario |
Canada | York Dermatology Clinic and Research Centre | Richmond Hill | Ontario |
Canada | Saskatoon Dermatology Centre | Saskatoon | Saskatchewan |
Germany | Dr. Bernhard Korge | Düren | NRW |
Germany | UKSH- Institut für Entzündungsmedizin | Lübeck | Schleswig-Holstein |
Germany | Dermatologische Gemeinschaftspraxis Mahlow | Mahlow | Bradenburg |
Spain | Hospital Clinic de Barcelona | Barcelona | |
Spain | Hospital Universitario La Princesa | Madrid | |
United States | Allergy Partners of Western North Carolina | Asheville | North Carolina |
United States | Montefiore Medical Center | Bronx | New York |
United States | Centurion Dermatology | Brooklyn | New York |
United States | The University of Buffalo | Buffalo | New York |
United States | UNC Dermatology | Chapel Hill | North Carolina |
United States | The Medical University of South Carolina | Charleston | South Carolina |
United States | Lurie Children's Hospital/Northwestern University | Chicago | Illinois |
United States | Ohio State University | Columbus | Ohio |
United States | Empire Dermatology | East Syracuse | New York |
United States | Windsor Dermatology | East Windsor | New Jersey |
United States | El Paso Dermatology Center | El Paso | Texas |
United States | Forest Hills Dermatology Group | Forest Hills | New York |
United States | Johnson Dermatology | Fort Smith | Arkansas |
United States | First OC Dermatology | Fountain Valley | California |
United States | Center for Dermatology Cosmetic and Laser Surgery | Fremont | California |
United States | North Texas Center for Clinical Research | Frisco | Texas |
United States | Feinstein Dermatology and Cosmetic Surgery | Hollywood | Florida |
United States | Dawes Fretzin Dermatology/ Dawes Fretzin Clinical Research Group | Indianapolis | Indiana |
United States | University of California | Irvine | California |
United States | The University of Kansas Medical Center | Kansas City | Kansas |
United States | Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire |
United States | Asthma and Allergy Center | Lewisville | Texas |
United States | South Lincoln Dermatology Clinic | Lincoln | Nebraska |
United States | Arkansas Dermatology | Little Rock | Arkansas |
United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
United States | Family Allergy and Asthma Research Institute | Louisville | Kentucky |
United States | North Sound Dermatology | Mill Creek | Washington |
United States | Children's Hospital of Wisconsin | Milwaukee | Wisconsin |
United States | University of Minnesota | Minneapolis | Minnesota |
United States | Carl Thornblade, MD, PLLC | Missoula | Montana |
United States | Dermatology Center for Skin Health | Morgantown | West Virginia |
United States | Allergy Associates of Utah | Murray | Utah |
United States | University of Utah MidValley Dermatology | Murray | Utah |
United States | Greenwich Village Dermatology | New York | New York |
United States | Ichan School of Medicine | New York | New York |
United States | Allergy, Asthma & Clinical Research Center | Oklahoma City | Oklahoma |
United States | Advanced Dermatology of the Midlands | Omaha | Nebraska |
United States | Allergy and Clinical Immunology | Pittsburgh | Pennsylvania |
United States | Oregon Health and Science University | Portland | Oregon |
United States | Integrated Dermatology of Massachusetts | Quincy | Massachusetts |
United States | Virginia Commonwealth University | Richmond | Virginia |
United States | Mayo Clinic | Rochester | Minnesota |
United States | DermAssociates, LCC | Rockville | Maryland |
United States | Advanced Allergy & Asthma, PLLC | Rockville Centre | New York |
United States | University of California - San Diego/Rady Children's Hospital | San Diego | California |
United States | Clear Dermatology & Aesthetics Center/Investigative MD | Scottsdale | Arizona |
United States | Spokane Dermatology Clinic | Spokane | Washington |
United States | Academic Alliance in Dermatology | Tampa | Florida |
United States | George Washington University | Washington | District of Columbia |
United States | Center for Clinical Studies | Webster | Texas |
United States | Integrated Dermatology of West Palm Beach | West Palm Beach | Florida |
United States | Wake Forest University Health Sciences | Winston-Salem | North Carolina |
United States | University of Massachusetts Medical School | Worcester | Massachusetts |
United States | Linda Susan Marcus | Wyckoff | New Jersey |
Lead Sponsor | Collaborator |
---|---|
Target PharmaSolutions, Inc. |
United States, Canada, Germany, Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Characterize IMISC Treatment Regimens in Clinical Practice | Enable characterization of IMISC disease activity and comorbid medical conditions over time. | 25 Years | |
Primary | Evaluate Patient Outcomes in Clinical Practice | Enable characterization of IMISC disease activity and comorbid medical conditions over time. | 25 Years | |
Primary | Evaluate Adverse Events of IMISC and treatment in Clinical Practice | Enable characterization of IMISC disease activity and comorbid medical conditions over time. | 25 Years | |
Secondary | Evaluate the relationship between IMISC and comorbid medical conditions | Inform clinical practice by identifying the occurrence and impact of comorbid medical conditions on treatment regimens, utilize patient reported outcomes, and evaluate patient support programs. | 25 Years | |
Secondary | Evaluate Patient Reported Outcome (PRO) measures | Inform clinical practice by identifying the occurrence and impact of comorbid medical conditions on treatment regimens, utilize patient reported outcomes, and evaluate patient support programs. | 25 Years | |
Secondary | Evaluate outcomes related to Patient Support Programs (PSPs) | Inform clinical practice by identifying the occurrence and impact of comorbid medical conditions on treatment regimens, utilize patient reported outcomes, and evaluate patient support programs. | 25 Years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03236870 -
A Study to Evaluate the Effectiveness and Patient-Reported Outcome of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in China
|
||
Completed |
NCT00078819 -
Etanercept (Enbrel®) in Psoriasis - Pediatrics
|
Phase 3 | |
Completed |
NCT04841187 -
Assessing the Long Term Effectiveness and Safety of Systemic Treatments in Cutaneous Psoriasis
|
||
Active, not recruiting |
NCT03927352 -
The Purpose of This Research Study is to Compare the Efficacy and Safety of SCT630 and Adalimumab (HUMIRA®) in Adults With Plaque Psoriasis
|
Phase 3 | |
Completed |
NCT03284879 -
Post-Marketing Surveillance Study of OTEZLA
|
||
Recruiting |
NCT06027034 -
Effectiveness of a Digital Health Application for Psoriasis
|
N/A | |
Not yet recruiting |
NCT06050330 -
CD4+ T Cells and S100A7 Epression in Normal and Psoriatic Skin: A Histological and Histochemical Study
|
N/A | |
Recruiting |
NCT05744466 -
A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis
|
||
Completed |
NCT04149587 -
A Study of Brodalumab (SILIQ®) in Psoriasis Participants With Inadequate Response to Their Current Biologic Agent Regimen
|
||
Completed |
NCT01384630 -
Safety, Pharmacokinetics, and Efficacy of RA-18C3 in Subjects With Moderate to Severe Psoriasis
|
Phase 2 | |
Completed |
NCT03998683 -
A Study of Guselkumab for the Treatment of Palmoplantar-non-Pustular Psoriasis
|
Phase 3 | |
Terminated |
NCT03556202 -
A Long-term Study to Evaluate Safety and Maintenance of Treatment Effect of LY3074828 in Participants With Moderate-to-Severe Plaque Psoriasis (OASIS-3)
|
Phase 3 | |
Completed |
NCT05051943 -
A Study of the Real-world Use of an Adalimumab Biosimilar and Evaluation of Nutritional Status on the Therapeutic Response
|
||
Recruiting |
NCT06077331 -
A Study to Evaluate Efficacy and Safety of HS-10374 for Moderate to Severe Plaque Psoriasis
|
Phase 2 | |
Completed |
NCT04316585 -
A Study to Evaluate the Benefit and Safety of GSK2982772 in Moderate to Severe Psoriasis Participants
|
Phase 1 | |
Completed |
NCT04894890 -
A Prospective Multicenter Study for the Assessment of Treatment Patterns, Effectiveness and Safety of Secukinumab in Adult Patients With Moderate to Severe Plaque Psoriasis in a Real-world Setting in China
|
||
Completed |
NCT00358384 -
Chronic Plaque Psoriasis Study With Topical Formulation Of GW786034
|
Phase 1 | |
Completed |
NCT03757013 -
A Study to Assess Benefits of Apremilast in Patients With Moderate to Severe Chronic Plaque Psoriasis Followed by Dermatologists Under Real Life Settings in France
|
||
Completed |
NCT03265613 -
Safety and Efficacy of Expanded Allogeneic AD-MSCs in Patients With Moderate to Severe Psoriasis
|
Phase 1/Phase 2 | |
Completed |
NCT05003531 -
A Study to Evaluate IBI112 in the Treatment of Subjects With Moderate to Severe Plaque Psoriasis
|
Phase 2 |