Psoriasis Clinical Trial
Official title:
Cutaneous Microcirculation and Nervous Sensitivity in Psoriasis
Psoriasis is a chronic inflammatory cutaneous disease, affecting 3% of the French population.
Among psoriatic patients, 80% feel pain or cutaneous discomfort related to their pathology.
Neurogenic inflammation's role in psoriasis has recently been put forward by a study showing
that TRPV1 ion channels are necessary to establish psoriasiform inflammation in mice.
The investigators hypothesize that there is a link between cutaneous sensory neuropathies and
altered cutaneous microcirculation during psoriasis.
In order to test this hypothesis, local vasodilators will be delivered to patients by
iontophoresis and their skin blood flow in response to these molecules will be followed by
laser Doppler recordings. Two recordings will be performed for each patient, both on a
psoriasis plaque and on uninvolved skin, in order for the patient to be his own internal
control.
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