Immunologic Response to Secukinumab in Plaque Psoriasis

Status Completed

Clinical Trial Summary

This is a single-arm, open-label study, which will examine the effect of secukinumab on the immunologic and genetic environment within psoriatic lesions.

Clinical Trial Description

Quantitative analysis of the immunologic changes in immune cell populations will be performed after secukinumab treatment in 15 patients at weeks 2, 4, and 12 compared to baseline week 0. The immunologic profiles in psoriasis patients will also be compared to healthy control skin surgical discard specimens (n=10). The number of differentially expressed genes in each cell population will be quantified by RNA-seq at weeks 2, 4, 12 after secukinumab compared to baseline. ;

Study Design

Related Conditions & MeSH terms

Psoriasis

Clinical Trial Details

NCT number	NCT02592018
Study type	Interventional
Source	University of California, San Francisco
Contact
Status	Completed
Phase	Phase 4
Start date	October 2016
Completion date	December 2018

View Details

See also
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