Prosthetic Fixation After Cementless Total Hip Arthroplasty Clinical Trial
Official title:
The Efficacy Study of Aclasta (Zoledronic Acid 5mg) on Prosthetic Fixation in Postmenopausal Women After Cementless Total Hip Arthroplasty (THA): a 24 Months, Single Center, Open- Label, Randomized, Parallel Controlled Study
It's to investigate the efficacy of Zoledronic acid treatment on the early prosthetic fixation in post-menopausal osteoporosis women under cementless total hip arthroplasty after 24-month observation.
To investigate the efficacy of Zoledronic acid and placebo treatment on the prosthetic
transverse translation in post-menopausal osteoporosis women under cementless total hip
arthroplasty by Radiostereometry （RSA）in two-year follow-up period .
Meanwhile to assess efficacy of Zoledronic acid treatment on the vertical translation of
acetabulum and the subsidence translation of femoral stem by Radiostereometry（RSA),
prevention of peri- prosthetic bone loss by observing the local average bone mineral density
( BMD ) changes for 7 femoral region Gruen zones through Dual Energy X-ray Absorptiometry
(DXA）scans, et al.
;