Prosthesis-related Infections Clinical Trial
Official title:
European Prosthetic Joint Infection Cohort Study (EPJIC): Evaluation of the Treatment Approach for Hip, Knee and Shoulder Prosthetic Joint Revision Surgery
The purpose of the study is to compare different approaches for the treatment of prosthetic joint revisions and to optimize the outcomes in patients with prosthetic joint infections (PJI) by improving the treatment concept of PJI.
The aim of the study is to assess the impact of different surgical and antibiotic therapies on patients admitted for a septic or aseptic revision of the hip, knee or shoulder prosthesis. The decision whether the implant will be retained or removed or antimicrobial treatment is based on criteria of each participating center specialists.The success of different treatment algorithms will be measured in terms of infection free interval, functional outcome and quality of life. All consecutive patients who need a revision surgery to the hip, knee or shoulder will be included. Furthermore the study will investigate different diagnostic tests (microbiological and histological) for the diagnosis and the discrimination of septic and aseptic causes in prosthesis failures. Pathogens (microorganisms isolated from puncture of the joint, tissue samples sonication fluid and blood) will be collected to establish a biobank.The samples are obtained preoperatively and intraoperatively as part of routine care practice. The study is not randomized. ;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01816009 -
Treatment of the Infections on Osteo-articular Prostheses by 6 Versus 12 Weeks of Antibiotherapy
|
Phase 3 | |
| Not yet recruiting |
NCT05582460 -
Exploring Novel Diagnostic Tools for Periprosthetic Joint Infection
|
||
| Completed |
NCT02127281 -
Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.
|
N/A | |
| Active, not recruiting |
NCT03121183 -
Medico-economic Evaluation of Strategies for the Lead Extraction of Implantable Defibrillator and Pacemakers
|
N/A | |
| Completed |
NCT04622280 -
Prospectively Observational Evaluation of Clinical Outcomes in Two-stage Revision for Periprosthetic Knee Infection
|
||
| Active, not recruiting |
NCT05113303 -
COREV 2.0 PMCF-Study on Manual and Navigated Revision Knee Patients
|
||
| Recruiting |
NCT04304885 -
Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.
|
||
| Recruiting |
NCT04520841 -
Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings
|
N/A | |
| Completed |
NCT01760863 -
Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty
|
N/A | |
| Completed |
NCT06089044 -
Evaluation of the Efficacy and Safety of Suppressive Therapy With DALBAVANCINE in Device Infections
|
||
| Recruiting |
NCT03444571 -
PRO-DIAG: Improved Diagnosis of Prosthetic Joint Infections
|
N/A | |
| Completed |
NCT03274466 -
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
|
N/A | |
| Completed |
NCT02860767 -
Dosing of Antibiotics During Reimplantation of Infected Knee and Hip Prostheses
|
N/A | |
| Completed |
NCT01175044 -
Dilute Betadine Lavage in the Prevention of Postoperative Infection
|
Phase 4 | |
| Recruiting |
NCT02376153 -
Air Barrier System for the Prevention of Prosthesis-related Infections
|
N/A | |
| Active, not recruiting |
NCT00423982 -
Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty
|
Phase 4 |