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Prostheses and Implants clinical trials

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NCT ID: NCT03566303 Terminated - Stroke Clinical Trials

Rivaroxaban vs Warfarin in Patients With Metallic Prosthesis

RIWA
Start date: July 10, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Mechanical heart valves (MHV) demand lifelong anticoagulation with vitamin K antagonists (VKA) due to the high thrombogenicity of the prosthesis. Rivaroxaban has previously been tested in experimental and animal models with encouraging results. The investigators recently sent for publication an experiment with 7 patients who used rivaroxaban in metallic prosthesis with encouraging results. In this way it was decided to do a randomized non-inferiority clinical trial comparing rivaroxaban with warfarin in patients with metallic prosthesis.