Prostatic Neoplasms Clinical Trial
Official title:
Establishment and Clinical Assessment of a Prostate Cancer (PCa) Risk Model Based on the Updated Circulating Tumor Cell (CTC) Detection Technique
1. To elucidate the role of CTC detection in the evaluation of risk level in PCa patients,
and establish a mathematic model for predicting the pathological status.
2. To explore the possible subtle change in CTC condition after radical prostatectomy.
1. Detect and evaluate the CTC status (a total of 3 times: 1 day before sugery, 3/12 months
after surgery) for all of the PCa patients enrolled. Analyze the CTC result with PSA
level, needle biopsy and radiological imaging information.
2. Analyze the difference in CTC amount/Epithelial-Mesenchymal ratio between patients in
different D'Amico risk level(low/intermediate/high).
3. Establish a mathematic model based on the CTC results and pathological condition
observed in operation (OC, organ confined; EPE, extraprostatic extension; SVI, seminal
vesicle invasion; LNI, lymph node invasion), and compare this model with the latest
version of Partin table.
4. Detect and compare the CTC and PSA level 3/12 months after surgery. Evaluate the
radiological condition in 12 months after blood draw.
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