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Prostatic Hypertrophy, Benign clinical trials

View clinical trials related to Prostatic Hypertrophy, Benign.

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NCT ID: NCT04331301 Completed - Clinical trials for Prostatic Hyperplasia

Bipolar Needlescopic Enucleation Versus Vapoenucleation of BPH

Start date: January 10, 2017
Phase: N/A
Study type: Interventional

Transurethral resection of the prostate (TURP) is the current standard procedure for men with prostate volume 30-80 gm. In case with large prostate adenoma (>80 g), the resection time required by TURP is associated with increased risk of TUR syndrome, blood loss and other complications. Many types of minimally invasive surgery exist along with new equipment and techniques. Many types of laser devices such as greenlight laser, thulium laser and holmium laser, are used to enucleate the prostate. Increasing evidence has proven their safety and efficacy However, the use of laser devices is difficult and associated with steep learning curve and high medical expenses. PKEP is a safe and effective procedure for the treatment of bladder obstruction secondary to BPH. This procedure not only improves maximum flow rate at 3 and 12 months after surgery, but it also improves all other recorded parameters (IPSS, QOL, IEFF-5, PVR, PSA). A button electrode can be effectively used to enucleate the prostate because of its powerful vaporisation and strong coagulation (B-TUEP technique) ,such as that with a holmium laser, thulium laser and greenlight laser. However its associated with short term complication as early irritative symptoms, Bulai reported that 16.7% of the patients suffering from early irritative symptoms while Geavlete reported that 11.4% of patient suffering from early irritative symptoms.

NCT ID: NCT02943070 Completed - Clinical trials for Benign Prostatic Hyperplasia

Rezum I Pilot Study for Benign Prostatic Hyperplasia

Rezum Pilot
Start date: March 2012
Phase: N/A
Study type: Interventional

Evaluate the safety and efficacy of the Rezum System for the treatment of BPH

NCT ID: NCT02940392 Completed - Clinical trials for Benign Prostatic Hyperplasia

Rezum FIM Optimization Study

Rezum FIM
Start date: March 19, 2012
Phase: N/A
Study type: Interventional

Evaluate the effect of the NxThera BPH Rezum System on prostate tissue in subjects suffering from LUTS symptoms secondary to benign prostatic hyperplasia (BPH).

NCT ID: NCT02074644 Completed - Clinical trials for Lower Urinary Tract Symptoms

Clinical Trial of Prostatic Arterial Embolization Versus a Sham Procedure to Treat Benign Prostatic Hyperplasia

Start date: September 2, 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether prostatic arterial embolization (PAE) compared is an effective and safe treatment for benign prostatic hyperplasia in patients with severe lower urinary tract symptoms not adequately controlled by medical therapy with alpha-blockers, as assessed by the the International Prostate Symptom Score (IPSS) after 6 months. Patients will be randomized on a 1:1 ratio to PAE or to a sham procedure and evaluated at 1, 3 and 6 months. Patients randomized to the sham procedure will be offered the possibility of performing PAE after 6 months. All patients may participate on an optional 6-months extension study.

NCT ID: NCT02015806 Completed - Breast Cancer Clinical Trials

Robust Evaluation to Measure Improvements in Nonadherence From Low-cost Devices

REMIND
Start date: March 2014
Phase: N/A
Study type: Interventional

The aim of this study is to determine whether adherence to oral maintenance medications differs for patients randomized to receive a RxTimerCap, a Take-N-Slide, a standard pillbox, or none of these devices, with the hypothesis that low-touch devices improve adherence over control and that the increase in adherence is agnostic across devices.

NCT ID: NCT01732991 Completed - Clinical trials for Prostatic Hypertrophy, Benign

Assessing the Impact of the PVP With Greenlight Laser Using Prostatic MRI and Contrast-enhanced Ultrasound

PROPIL
Start date: September 2012
Phase: N/A
Study type: Interventional

The PVP by Greenlight laser 180W is becoming a potential therapeutic alternative in the treatment of benign prostatic hypertrophy (BPH) as recommended. The PVP creates a prostatic box after the vaporization of the prostatic tissue of BPH. The underlying prostatic tissue is the site of an ischemic necrosis secondary to the thermal effects of proximity of the PVP. We intend to measure by prostatic MRI and contrast-enhanced ultrasound the necrosis.

NCT ID: NCT00461123 Completed - Clinical trials for Prostatic Hypertrophy, Benign

Vardenafil in Greenlight(TM) Laser Surgery of Benign Prostate Hypertrophy

Start date: March 2007
Phase: Phase 2
Study type: Interventional

The greenlight laser has an absorption maximum which is exactly the same as for hemoglobin. In the presence of hemoglobin, its application causes vaporization of the tissue and this effect depends on the concentration of hemoglobin in the respective tissue. Therefore, increase of blood-flow in the tissue (here: prostate gland) should exert better efficacy of the laser application and consequently shortening of the required duration of laser application.

NCT ID: NCT00021814 Completed - Clinical trials for Prostatic Hyperplasia

Medical Therapy of Prostatic Symptoms

MTOPS
Start date: December 1995
Phase: Phase 3
Study type: Interventional

The Medical Therapy of Prostatic Symptoms (MTOPS) is a clinical research study sponsored by the National Institutes of Health (NIH). The study will test whether the oral drugs finasteride (Proscar) and doxazosin (Cardura), alone or together, can delay or prevent further worsening of symptoms in men with Benign Prostatic Hyperplasia (BPH). MTOPS is the largest and longest study to simultaneously test whether these drugs can delay or prevent the clinical progression (symptom worsening) of BPH. Seventeen U.S. medical centers recruited 2,931 men diagnosed with symptomatic BPH between December 1995 and March 1998. Study doctors will continue to follow these men through November 2001 on a quarterly basis. In addition to the clinical progression of BPH, MTOPS will include evaluations of prostate volume by ultrasound, prostate biopsies among a subgroup of volunteers, and quality of life.