Orthopedic Disorder Clinical Trial
Official title:
Investigation of the Effect of Total Knee Arthroplasty on Proinflammatory Cytokine Level, Pain Severity, Functional Status, Joint Position Sense and Radiographic Findings
Knee osteoarthritis is a common disease that causes pain and loss of function. Total Knee Arthroplasty (TKA) is a frequently used surgical method in the treatment of severe knee osteoarthritis. The aim of this study was to investigate the effect of TKA on IL-6, TNF-α and IL-1β cytokine levels, pain intensity at rest and walking, knee joint valgity angle,malaligment, functional status and knee joint position sense.
Twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the TKA group (study group) and 22 patients (female/male:13/9) with <grade 4 osteoarthritis were included in the control group. Systemic venous blood samples of the patients were taken to evaluate the cytokine level (IL-6, TNF-α, IL-1). The Visual Analogue Scale was used to assess pain intensity, and the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score was used to evaluate the functional status. Valgity and malaligment measurements were calculated using antero-posterior X ray Digital goniometer was used to evaluate the knee joint position sense (at 35, 55 and 70 degrees knee flexion angles). Measurements were taken once from patients in the control group, and twice in pre-op and post-op sixth weeks from study group. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05864833 -
METabolism After Orthopedic Surgery
|
||
Completed |
NCT03286543 -
Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System
|
N/A | |
Recruiting |
NCT05461326 -
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
|
N/A | |
Completed |
NCT06080685 -
Efficacy of Character Strengths Intervention in Enhancing Character Strengths and Self-esteem Among Adolescents
|
N/A | |
Not yet recruiting |
NCT06326827 -
In'Oss™ (MBCP® Putty) Ortho
|
||
Not yet recruiting |
NCT06002009 -
SupraScapular Cuff Study: Assessing the Effects of Size and Type of Rotator Cuff Tear on Suprascapular Nerve Function
|
||
Completed |
NCT04730115 -
Evaluation of Architectural Changes in Mandibular Bone Pattern After Functional Treatment by Fractal Dimension Analysis
|
||
Withdrawn |
NCT03436667 -
Perioperative Factors Impacting Surgical Risk and Outcomes in Children
|
||
Completed |
NCT03299920 -
Opioid Consumption After Knee Arthroscopy
|
N/A | |
Active, not recruiting |
NCT05075525 -
EFFECT OF HIGH INTENSITY LASER IN PATELLOFEMORAL PAIN SYNDROME
|
N/A | |
Completed |
NCT06158165 -
Evaluating The Cardiovascular Effects of Tourniquet Application
|
||
Recruiting |
NCT04891549 -
Tension Band Versus Locking Plate Fixation for the Treatment of Patella Fractures
|
N/A | |
Recruiting |
NCT04676841 -
Wound Contamination During Orthopaedic Surgery
|
||
Not yet recruiting |
NCT03899298 -
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
|
Phase 1 | |
Completed |
NCT04514601 -
A Quality Improvement Project to Assess and Refine the Handover Process at Morning Trauma Meetings
|
||
Not yet recruiting |
NCT04546594 -
Epidemiological Data on Pain
|
||
Completed |
NCT05396924 -
Rectal Temperature Measurement in Detecting Hypothermia During Hip Arthroscopy
|
N/A | |
Active, not recruiting |
NCT06438835 -
Development & Evaluation of Pneumatic Artificial Muscle(PAM) for Patients With Ankle Foot Orthosis(AFO)
|
N/A | |
Active, not recruiting |
NCT05795127 -
Risk for Reoperation After First MTP Joint Arthrodesis
|
||
Completed |
NCT05928663 -
The Effect of Using Double Gloves on Perforation in Orthopedic Surgery
|
N/A |