Progressive Supranuclear Palsy (PSP) Clinical Trial
Official title:
Human CNS Tau Kinetics in Tauopathies
The goal of this study is to characterize tau kinetics and tau aggregation in the human CNS and to test the hypothesis that tau kinetics are altered (i.e. increased production, decreased clearance, and increased aggregation rate) in tauopathies.
Tauopathies are neurodegenerative diseases with tau pathology. These tauopathies are the most common pathology in neurodegenerative diseases, and they are reaching epidemic proportions. The rates of tau kinetics are central to understanding normal and abnormal processing and production and clearance of tau kinetics in humans to help understand the causes of tauopathy and evaluate tau-targeted therapeutics. This study will utilize the Stable Isotope Labeling Kinetics (SILK) method to elucidate tau kinetics in vivo in the human central nervous system (CNS) and its alteration in tauopathies. A total of ~34 participants from 3 different neurodegenerative diseases: Frontotemporal Dementia (FTD), Corticobasal Degeneration (CBD), and Progressive Supranuclear Palsy (PSP), will be invited to enroll in the study. Participants will be labeled with stable isotopes via 16hr intravenous infusion and CSF samples collected during subsequent lumbar puncture visits over ~120 days. CSF will be analyzed over time for the quantitation of labeled tau. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02365922 -
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
|
||
| Recruiting |
NCT03030586 -
ADDIA Proof-of-Performance Clinical Study
|
||
| Recruiting |
NCT02778607 -
PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK
|
||
| Completed |
NCT02531360 -
Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies
|
Phase 0 | |
| Completed |
NCT02133846 -
Safety Study of TPI-287 to Treat CBS and PSP
|
Phase 1 | |
| Recruiting |
NCT04363684 -
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
|
||
| Completed |
NCT04193527 -
A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients
|
Phase 3 | |
| Completed |
NCT02839642 -
Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy
|
Phase 3 | |
| Terminated |
NCT03391765 -
An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP)
|
Phase 2 | |
| Active, not recruiting |
NCT02966145 -
4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
|
||
| Completed |
NCT02103894 -
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
|
Phase 1 | |
| Active, not recruiting |
NCT04539041 -
Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of NIO752 in Progressive Supranuclear Palsy
|
Phase 1 | |
| Completed |
NCT01888185 -
Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)
|
||
| Completed |
NCT03413319 -
Extension Study of ABBV-8E12 in Patients With Progressive Supranuclear Palsy (PSP) Who Completed Study C2N-8E12-WW-104
|
Phase 1 |