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Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis — MAXIMS  

Progressive Multiple Sclerosis Clinical Trial

Official title:
A 96-Week, Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study to Compare Efficacy and Safety of Masitinib Dose Titration to 4.5 mg/kg/Day Versus Placebo in the Treatment of Patients With Primary Progressive or Secondary Progressive Multiple Sclerosis Without Relapse

Clinical Trial Summary

To evaluate the efficacy and safety of oral masitinib versus placebo in the treatment of patients with primary progressive or secondary progressive multiple sclerosis without relapse.

Clinical Trial Description

Masitinib is a selective tyrosine kinase inhibitor, targeting innate immune cells (mast cells and microglia) that are involved in the pathophysiology of progressive multiple sclerosis (MS). This is a multicenter, double-blind, randomized, placebo-controlled, comparative study of oral masitinib in the treatment of patients with progressive MS who were progressing but not clinically active. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05441488
Study type Interventional
Source AB Science
Contact Clinical Study Coordinator
Phone +33(0)147200014
Email clinical@ab-science.com
Status Recruiting
Phase Phase 3
Start date June 28, 2022
Completion date December 2025
View Details
See also
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