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Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML)

Progressive Multifocal Leukoencephalopathy Clinical Trial

Official title:
A Randomized, Rater-Blinded Study to Explore the Effect of Mefloquine in Subjects With Progressive Multifocal Leukoencephalopathy (PML)

Clinical Trial Summary

The primary objective of the study was to explore whether mefloquine can delay or stop progression of progressive multifocal leukoencephalopathy (PML) as measured by JC virus (human polyomavirus or JCV) deoxyribonucleic acid (DNA) levels in cerebrospinal fluid (CSF). The secondary objective of the study was to explore whether mefloquine can delay or stop progression of PML based on neurological deterioration, magnetic resonance imaging (MRI) measures of brain lesion evolution or the formation of new lesions, and mortality.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

  • Leukoencephalopathies
  • Leukoencephalopathy, Progressive Multifocal
  • Progressive Multifocal Leukoencephalopathy
Clinical Trial Details
NCT number NCT00746941
Study type Interventional
Source Biogen
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date January 2009
Completion date November 2010
View Details
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