Progressive Keratoconus Clinical Trial
Official title:
Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Hypo-osmolar Riboflavin Solution in Thin Corneas
The purpose of this study is to evaluate the corneal pachymetric variations during and after corneal collagen cross-linking (CXL) treatment with ultraviolet-A irradiation (UVA) and hypo-osmolar riboflavin solution in thin corneas.
To evaluate the corneal pachymetric variations during and after corneal collagen
cross-linking (CXL) treatment with ultraviolet-A irradiation (UVA) and hypo-osmolar
riboflavin solution in thin corneas.
Eighteen eyes of 18 patients, 11 men and 7 women, with progressive keratoconus and thinnest
corneal thickness (TCT) less than 400µm were included in this study.
After the epithelium removal, iso-osmolar riboflavin was applied to the cornea every 3
minutes (30 min). Hipo-osmolar riboflavin was then applied every 20 seconds until the TCT
reached 400µm. UVA irradiation was performed for 30 min. Pachymetry was recorded at the
thinnest point of the cornea preoperatively, after epithelial removal, after iso-osmolar
riboflavin, after hypo-osmolar riboflavin, after UVA irradiation, and at 1, 6 and 12 months.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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