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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05184153
Other study ID # 87RI20_0072 (MEDCCR)
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 3, 2020
Est. completion date September 1, 2021

Study information

Verified date September 2021
Source University Hospital, Limoges
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Retrospective cohort of 10 cases of colonic adenocarcinoma of medullary type, operated between 2000 and 2020 at the University Hospital of Limoges. Collection of relevant data for this rare entity. Subgroup analysis in search of prognostic factors. Comparison of the data from our cohort with those from the literature.


Description:

Colorectal cancer (CRC) is the third most common cancer in the world after breast and prostate cancer (1). It is also the second most common cause of cancer death in France (2). Most CRCs are adenocarcinomas. However, there is a distinct subtype of adenocarcinoma of relatively recent recognition, called medullary carcinomas (MC). Its recent recognition as a distinct entity (3) has made it difficult to study the epidemiologic characteristics of this cancer, with little population-based data. The largest cohort studied in the literature is from a US sample of 74 patients seen between 1973 and 2006 (4). The main objective of this French retrospective study is to highlight some common features in this group of patients with medullary colorectal cancers, thus improving our knowledge of this cancer subtype and in particular its prognosis. Medullary colorectal cancer is a type of cancer with a prognosis of its own, probably different from the most common histological entity, colorectal adenocarcinoma. This is a retrospective study a cohort of 10 cases of colonic adenocarcinoma of medullary type, operated between 2000 and 2020 at the University Hospital of Limoges. A collection of relevant data was realised for the subgroup analysis in search of prognostic factors for this rare entity as well as a comparison of the data from this cohort with those from the literature.


Recruitment information / eligibility

Status Completed
Enrollment 10
Est. completion date September 1, 2021
Est. primary completion date December 19, 2020
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Pathological diagnosis of colorectal adenocarcinoma of medullary type between 2000 and 2020 Exclusion Criteria: - Absence of anatomopathological confirmation on the surgical specimen

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France Service de Chirurgie Digestive et Endocrinienne du CHU de Limoges Limoges

Sponsors (1)

Lead Sponsor Collaborator
University Hospital, Limoges

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Survival Number of days between diagnosis and death Through study completion in April 2021
Secondary Progression Number of days between first surgery and appearance of metastases Through study completion in April 2021
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