Production of Vitamin D in Skin When Exposed to UV-B by Solar Bed. Clinical Trial
Official title:
Production of Vitamin D Metabolites by UV-radiation From Solar Bed
Background:
Some patients do not readily absorb vitamin D from intestine. These patients may be helped
by ultraviolet rays, which can come from sunlight or solar beds. When the skin is exposed to
ultraviolet B rays (UVB) vitamin D is produced. This usually happens when the skin is
exposed to sunlight. Vitamin D can also be ingested trough some foods, mainly fatty fish or
supplements.
Vitamin D is important for bone, and long-term vitamin D deficiency can lead to
osteoporosis. Vitamin D may also be important for the immune system—including autoimmune
diseases—and the cardiovascular system.
Purpose:
The main purpose of the study is to learn more about the production of vitamin D3 in the
skin, by ultraviolet radiation.
Study Course:
Day 0: Randomization. Subjects are randomized to two groups. Subjects in both groups will be
exposed to light in a solar bed for approximately 10 minutes on the first day, but only one
of the solar beds wields ultraviolet rays. The other has a filter, which filters out the
ultraviolet rays.
Blood samples are drawn on the first day at following times: Before solar bed, after at 15
minutes, 1, 2, 4 and 6 hours.
Day 1,2,3 and 7 after solar bed exposure:
Blood samples are drawn and adverse events are registered.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science