Pain Clinical Trial
Official title:
Efficacy of Oral Sucrose Analgesia During Routine Immunizations at 6 Weeks and 4 Months of Age
The study explores the potential benefits of a sugar water solution for decreasing pain in infants during routine immunizations.
Acute pain during early life may alter infant pain responses, cognitive development, and
behavioral outcomes. Immunization injections represent a relatively brief exposure to acute
pain, yet assessment studies demonstrate that infants respond with significant distress
during the injections. This study will examine the analgesic potential of oral sucrose in
diminishing the pain associated with immunization injections in 6 week to 4-month-old
infants. The proposed mechanism of action is via the activation of endogenous opioids that
attenuate nociceptive information at the level of the dorsal horn.
Comparison: Administration of oral sucrose 2 minutes prior to immunizations compared to
administration of sterile water 2 minutes prior to immunizations
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