First Clinical Live-Donor Uterus Transplantation Trial In Egypt

Primary Uterine Infertility Clinical Trial

Official title: First Clinical Live-Donor Uterus Transplantation Trial In Egypt

Status Not yet recruiting

Clinical Trial Summary

More than a decade ago, uterus transplantation (UTx) as a highly experimental procedure was the treatment which had been developed for women suffering from absolute uterine factor infertility (AUFI) [uterus absence (congenital and surgical), or an abnormality (anatomic and functional)]. In Egypt, People's religions, current ethical and legal backgrounds make the option of live-donor uterus transplantation appealing rather than alternative pathways to parenthood. Thus, its clinical application for the first time in Egypt should be initiated after an extensive review and analysis of literature for UTx technology development in the world, and for further possible contributions to future prospects by Egypt proposed UTx project team which will participate in our study.

Clinical Trial Description

More than a decade ago, uterus transplantation (UTx) as a highly experimental procedure was the treatment which had been developed for women suffering from absolute uterine factor infertility (AUFI) [uterus absence (congenital and surgical), or an abnormality (anatomic and functional)]. In Egypt, People's religions, current ethical and legal backgrounds make the option of live-donor uterus transplantation appealing rather than alternative pathways to parenthood. Thus, its clinical application for the first time in Egypt should be initiated after an extensive review and analysis of literature for UTx technology development in the world, and for further possible contributions to future prospects by Egypt proposed UTx project team which will participate in our study. The study protocol includes live-donor UTx (mother, relative, friend) into women with AUFI. The recipient will be treated by standard immunosuppression and transfer of embryos (acquired by IVF before surgery) will be attempted after 8-12 months have passed from transplantation. Two official approvals must be obtained before starting recruitment process; from both (Higher Committee of Human Organ Transplantation of Egyptian Ministry of Health and Population, and Al-Azhar University Council). ;

Related Conditions & MeSH terms

• Infertility
• Primary Uterine Infertility

• NCT number: NCT03284073
• Study type: Interventional
• Source: Talkha Central Hospital
• Contact: Amro M. Hetta, M.Sc.
• Phone: +201281283482
• Email: doctor.hetta@gmail.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 1, 2021
• Completion date: October 31, 2022