Cutaneous Silent Period Assessment in Primary Sjögren's Syndrome

Status Completed

Clinical Trial Summary

Primary Sjögren's syndrome (pSS) is a chronic, immune-mediated inflammatory disease mainly characterized by exocrine gland involvement. Beyond the wide heterogeneity in clinical presentation, neurological manifestation is one of the important systemic involvement of pSS. The prevalence of neurological involvement varies widely from 10% to 60% in different series. Small fiber neuropathy (SFN) as a popular clinical entity in recent years targets nociceptive thinly myelinated A-delta and unmyelinated C-fiber nerves and is frequently associated with burning and allodynic pain. Previous studies have demonstrated that SFN is frequently seen in patients with pSS and has an important clinical importance because it cannot be detected by routine electrophysiological studies. Various methods can be used in the detection of SFN, and cutaneous silent period (CSP) measurement is gaining popularity recently due to its non-invasiveness and practical fashion. In this study, the investigators aimed to compare CSP parameters as an indicator of SFN in patients with pSS and in the healthy population and to reveal its relationship with clinical parameters.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05380804
Study type	Observational
Source	Marmara University
Contact
Status	Completed
Phase
Start date	January 4, 2021
Completion date	February 28, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02537951` - Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study	N/A
Completed	`NCT01911975` - Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy	Phase 3
Completed	`NCT03304522` - A Study to Evaluate the Efficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy	Phase 2
Recruiting	`NCT04310644` - Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry
Completed	`NCT03912220` - Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration	Phase 2
Completed	`NCT03401073` - IVIg for Small Fiber Neuropathy With Autoantibodies TS-HDS and FGFR3	Phase 2
Recruiting	`NCT03889080` - fMRI-study in Patients With Small Fiber Neuropathy
Completed	`NCT03447756` - Titration Study of ABX-1431	Phase 1
Recruiting	`NCT04835779` - Biometric and Biological Data for Diagnosis and Therapy of Pain Patients
Suspended	`NCT04611048` - Establishing Normative Values for Thermal Detection and Pain Threshold Established by the Psi Method	N/A
Not yet recruiting	`NCT04170205` - Causes Associated With Small Fiber Neuropathy (SFN).
Recruiting	`NCT05389566` - Diabetes, Falls, and Fractures
Terminated	`NCT03339336` - Efficacy and Safety Study of BIIB074 in Participants With Small Fiber Neuropathy	Phase 2
Recruiting	`NCT05798949` - Chronic Pain Rehabilitation in Patients With Small Fiber Neuropathy	N/A
Enrolling by invitation	`NCT05921097` - Comparison of Histamine and Local Heating for Evoking the Axon-reflex Flare Response in Diabetes
Completed	`NCT02637700` - Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy	Phase 2
Recruiting	`NCT04759443` - Detection of Small Fiber Neuropathy Using Skin Properties
Terminated	`NCT02905396` - Spinal Cord Stimulation in Small Fibre Neuropathy	N/A
Recruiting	`NCT03509064` - Medico-economic and Quality of Life Impact of Sjogren-associated Small Fiber Neuropathy
Completed	`NCT05993871` - Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study