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Efficacy, Safety and Immunological Evaluation of Tofacitinib in the Treatment of Primary Sjogren's Syndrome

Primary Sjögren's Syndrome Clinical Trial

Official title:
Efficacy, Safety and Immunological Evaluation of Tofacitinib in the Treatment of Primary Sjögren's Syndrome:a Prospective Observational Study

Clinical Trial Summary

This study aims to explore the clinical and immunological efficacy of tofacitinib on primary Sjögren's Syndrome

Clinical Trial Description

The investigators designed a single center, open-label, prospective study. Adults with active primary Sjögren's Syndrome will be enrolled, meeting the American College of Rheumatology(ACR) & European allance of associations for rheumatology(EULAR)(2016) diagnostic criteria . Tofacitinib 5 mg bd was administered for 6 months to explore its efficacy and safety. The improvement of clinical and laboratory indexes was evaluated. Changes of immune cell subsets and cytokines were monitored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05087589
Study type Interventional
Source Peking University People's Hospital
Contact Qinghong Liu
Phone +86 15774917676
Email 166618530@qq.com
Status Recruiting
Phase Phase 2
Start date November 20, 2021
Completion date October 1, 2023
View Details
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