Primary Sjögren's Syndrome Clinical Trial
Official title:
Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity
Primary Sjögren's syndrome (pSS) can affect various organs, sometimes leads to life-threatening conditions and is always responsible for a decreased quality of life. Its evolution is chronic, with flares and relapses, and the need for reliable biomarkers to be carried out routinely is major in patients' follow-up. Because of the existence of autoreactive immunoglobulins E (IgE) in autoimmune diseases, the recently described role for anti-Ro/SSA antibodies in inducing interferon alpha (IFNα) signaling and the specific pharmacologic properties of IgE, anti-Ro/SSA IgE should be an interesting biomarker to determine pSS's activity. The aim of the study is to evaluate whether the proportion of anti-Ro/SSA IgE positive patients is higher in patients with active disease (i.e. Eular Sjögren Syndrome Disease Activity Index≥ 5). All consecutive patients with pSS (new or already known diagnosis) will be included, Anti-Ro/SSA IgE titers will be determined, the disease's features will be collected (including Eular Sjögren Syndrome Disease Activity Index/Eular Sjogren's Syndrome Patient Reported Index).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03040583 -
The ASSESS National Multi-center Prospective Cohort
|
||
| Completed |
NCT01989819 -
Primary Sjögren Syndrome
|
||
| Completed |
NCT02291029 -
Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sjögren's Syndrome
|
Phase 2 | |
| Terminated |
NCT02610543 -
UCB Proof of Concept Study in Patients With Primary Sjögren's Syndrome
|
Phase 2 | |
| Not yet recruiting |
NCT04975087 -
The Profile of Fatigue and Discomfort - Sicca Symptoms Inventory
|
||
| Completed |
NCT04078386 -
A Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Primary Sjögren's Syndrome
|
Phase 2 | |
| Recruiting |
NCT05087589 -
Efficacy, Safety and Immunological Evaluation of Tofacitinib in the Treatment of Primary Sjogren's Syndrome
|
Phase 2 | |
| Recruiting |
NCT04212572 -
Ultrasound Abnormalities of the Salivary Glands in Primary Sjögren's Syndrome According to the Duration of the Disease
|
||
| Completed |
NCT02149420 -
PD of VAY736 in Patients With Primary Sjögren's Syndrome
|
Phase 2 | |
| Recruiting |
NCT04858464 -
Reliability, Validity of the Turkish Version of the Primary Sjögren Syndrome Quality of Life (PSS-QoL) Questionnaire
|
||
| Completed |
NCT00632866 -
Hydroxychloroquine Versus Placebo in Primary Sjögren's Syndrome
|
Phase 3 | |
| Completed |
NCT02334306 -
A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sjögren's Syndrome
|
Phase 2 | |
| Completed |
NCT02775916 -
Safety, Pharmacokinetics, and Preliminary Efficacy Study of CDZ173 in Patients With Primary Sjögren's Syndrome
|
Phase 2 | |
| Completed |
NCT02464319 -
A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sjögren's Syndrome
|
Phase 2 | |
| Terminated |
NCT01552681 -
Baminercept, a Lymphotoxin-Beta Receptor Fusion Protein, for Treatment of Sjögren's Syndrome
|
Phase 2 | |
| Completed |
NCT04186871 -
Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis
|
Phase 2 | |
| Completed |
NCT00426543 -
Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome
|
Phase 2 | |
| Recruiting |
NCT04981145 -
The Efficacy and Safety of Iguratimod (IGU) in the Treatment of Primary Sjögren's Syndrome
|
Phase 4 | |
| Completed |
NCT06432101 -
Acupuncture Combined With Hydroxychloroquine
|
N/A | |
| Completed |
NCT03627065 -
A Study of INCB050465 in Primary Sjögren's Syndrome
|
Phase 2 |