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NCT00537004 Clinical Trial

Language in Primary Progressive Aphasia

Primary Progressive Aphasia Clinical Trial

Official title:
Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00537004
Other study ID # IA0125
Secondary ID R01AG077444
Status Recruiting
Phase
First received
Last updated
Start date May 2007
Est. completion date April 2027

Study information
Verified date March 2024
Source Northwestern University
Contact Seyi Adeolu
Phone 312-503-2398
Email PPA.Research@northwestern.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.

Description:

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies. During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures. For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.

Recruitment information / eligibility
Status Recruiting
Enrollment 500
Est. completion date April 2027
Est. primary completion date April 2027
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Diagnosis of primary progressive aphasia - Right-handed - Native English speaker - Visual acuity of 20/30 corrected - Adequate hearing to follow conversation - Safe for an MRI scan Exclusion Criteria: - Left-handedness - Claustrophobia - Presence of significant medical illness that initially or in the future could interfere with continued participation in the study

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Northwestern University Chicago Illinois

Sponsors (2)
Lead Sponsor Collaborator
Northwestern University National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

References & Publications (2)

Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982 Jun;11(6):592-8. doi: 10.1002/ana.410110607. — View Citation

Weintraub S, Rubin NP, Mesulam MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol. 1990 Dec;47(12):1329-35. doi: 10.1001/archneur.1990.00530120075013. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Neuropsychological variables Immediately after testing and at two years post-testing
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