Primary Open Angle Glaucoma Clinical Trial
— ADAGESOfficial title:
African Descent and Glaucoma Evaluation Study (Formerly African Americans With Glaucoma Study)
Verified date | July 2021 |
Source | University of California, San Diego |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
According to the National Eye Institute, Glaucoma affects about three million Americans. Among Blacks in the United States, open- angle glaucoma is the leading cause of irreversible visual loss. Glaucoma is four times more likely to develop in Blacks than in Whites. This is a prospective longitudinal, multi- site observational cohort study designed to obtain visual function and optic nerve structure data on eyes of Black and White Americans. The investigators will evaluate the relationship between changes in the structure of the eye and the vision loss caused by glaucoma.This is the first study where both populations are matched for quality of care and equal access to care.
Status | Enrolling by invitation |
Enrollment | 1540 |
Est. completion date | July 2022 |
Est. primary completion date | January 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Open angles - Best-corrected acuity of 20/40 or better - Spherical refraction within + 5.0 D, and cylinder within + 3.0 D with plus OR minus cylinders - = 18 years old - A family history of glaucoma is allowed - Ability to obtain adequate or better quality stereophotographs - Ability to do reliable standard Humphrey 30-2 or 24-2 visual fields - Participants with glaucoma or at risk for glaucoma or healthy controls Exclusion Criteria: - History of intraocular surgery (except uncomplicated cataract or glaucoma surgery) - Problems other than Glaucoma affecting color vision - Non glaucomatous secondary causes of elevated IOP ( e.g. iridocyclitis, trauma) - Other intraocular eye disease - Other diseases affecting visual field (e:g pituitary lesions, demyelinating diseases, HIV+ or AIDS, or diabetic retinopathy) with medications known to affect visual field sensitivity - Problems other than Glaucoma affecting color vision |
Country | Name | City | State |
---|---|---|---|
United States | University of Alabama-Callahan Eye Foundation, Prof. Bldg. | Birmingham | Alabama |
United States | UCSD Hamilton Glaucoma Center | La Jolla | California |
United States | New York Eye & Ear Infirmary | New York | New York |
Lead Sponsor | Collaborator |
---|---|
University of California, San Diego | National Eye Institute (NEI) |
United States,
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Stamper R. L., Sample P. A. and Girkin C. A. (Eds.). (2003). Assessing Visual Function in Clinical Practice. Ophthalmology Clinics of North America, Vol.16, Number . In Anderson D.R.(ed.) Standard Perimetry (pp. 205-212).
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Stamper R. L., Sample P. A. and Girkin C. A. (Eds.). (2003). Assessing Visual Function in Clinical Practice. Ophthalmology Clinics of North America, Vol.16, Number 2. In Racette L and Sample P.A. (eds.). Short wave automated perimetry. (pp227 -236).
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Yamagishi N, Anton A, Sample PA, Zangwill L, Lopez A, Weinreb RN. Mapping structural damage of the optic disk to visual field defect in glaucoma. Am J Ophthalmol. 1997 May;123(5):667-76. — View Citation
Zangwill L, Knauer S, Williams JM, Weinreb RN, Retinal fiber layer assessment by scanning laser polarimetery, optical coherence tomography and retinal nerve fiber layer photography. In: Lemij HG, Schuman JS, eds. The Shape of Glaucoma, Quantitative Neural Imaging Techniques. The Hague Kugler Publications, 2000:239-252
* Note: There are 30 references in all — Click here to view all references
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