Primary Liver Cancer Clinical Trial
Official title:
A Randomized, Controlled Study to Evaluate the Efficacy and Significant of the Anti-virus Therapy for the Unresectable Hepatitis B Virus-related Primary Liver Cancer
This study is working to research the efficacy and significant of the anti-virus therapy in the unresectable Hepatitis B virus (HBV) related primary liver cancer(PLC) so as to establish treatment standards of anti-virus therapy in PLC.
primary liver cancer(PLC)is one of the world's most common malignancies, especially in
East-Asian countries.Hepatitis B virus (HBV) infection is associated with 70-90% of PLC
cases in China. PLC can develop during any stage of the natural course of chronic HBV
infection and anti-virus therapy should be considered during the management of PLC. However,
there is no definite guide on when or how to practice the anti-virus therapy, especially in
unresectable or inoperable PLC. Because of these facts, research on the significant of the
anti-virus therapy in the HBV-related PLC is urgently needed.
200 patients will be randomly assigned to anti-virus therapy group and control gruop.The
time to progression(TTP) and overall survival within two years will be used to evaluate the
effect of anti-virus therapy on PLC.
The aim of this study is to research the efficacy and significant of the anti-virus therapy
in the unresectable HBV-related PLC so as to establish treatment standards of anti-virus
therapy in PLC.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03161925 -
Chinese Liver Cancer Clinical Survey
|
N/A | |
| Completed |
NCT00261378 -
Prospective Randomised Study of Doxorubicin in the Treatment of Hepatocellular Carcinoma by Drug-Eluting Bead Embolisation
|
Phase 2 | |
| Enrolling by invitation |
NCT05609448 -
MRI-guided Holmium-166 Radioembolization
|
N/A | |
| Recruiting |
NCT05714124 -
Liver Embolization Approaches for Tumor Management
|
||
| Not yet recruiting |
NCT05353894 -
Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GNS561 After One Single Dose (50 and 200mg) in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT03518632 -
Preoperative Physical Activity Intervention in Patients Before Planned Liver Resection for Cancer (APACHE)
|
N/A | |
| Terminated |
NCT00003530 -
Antineoplaston Therapy in Treating Patients With Primary Liver Cancer
|
Phase 2 | |
| Recruiting |
NCT04806464 -
Clinical Study of VG161 in Subjects With Advanced Primary Liver Cancer
|
Phase 1 | |
| Recruiting |
NCT06342414 -
An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
|
||
| Completed |
NCT01116804 -
Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)
|
Phase 1 | |
| Recruiting |
NCT03067493 -
RFA or Surgical Resection Combined With Neo-MASCT for Primary HCC: a Phase II Trial
|
Phase 2 | |
| Completed |
NCT05183776 -
Clinical Validation of a Fractional Administration Device for Holmium-166 SIRT
|
N/A | |
| Recruiting |
NCT05677724 -
Single-cell RNA Sequencing Resolves the Regulatory Role of HBV on the Hepatocellular Carcinoma Immune Microenvironment
|
||
| Not yet recruiting |
NCT03178929 -
Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma
|
N/A | |
| Recruiting |
NCT05267080 -
Registry on Percutaneous Electrochemotherapy
|
||
| Not yet recruiting |
NCT02327819 -
The Effect of Branched-chain Amino Acid (BCAA) on the Progression of Primary Liver Cancer
|
N/A | |
| Completed |
NCT01640522 -
Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms
|
N/A | |
| Completed |
NCT00408122 -
Evaluation of Preoperative Investigations in Patients With Liver Cancer
|
N/A | |
| Recruiting |
NCT03297255 -
Primary Liver Cancer Cohort of South China
|
N/A | |
| Recruiting |
NCT06325267 -
Clinical Characteristics of Primary Liver Cancer
|