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Primary Dystonia clinical trials

View clinical trials related to Primary Dystonia.

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NCT ID: NCT04727177 Recruiting - Clinical trials for Transcranial Magnetic Stimulation

Precision-targeted Transcranial Magnetic Stimulation in the Treatment of Primary Dystonia

Start date: November 1, 2020
Phase: Early Phase 1
Study type: Interventional

In this scheme, TMS treatment of Primary dystonia is planned by precise magnetic resonance positioning.

NCT ID: NCT04071847 Recruiting - Parkinson Disease Clinical Trials

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

ADROIT
Start date: November 26, 2019
Phase:
Study type: Observational

The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.

NCT ID: NCT02073630 Completed - Primary Dystonia Clinical Trials

Contribution of the Cerebellum In Sensory-motor Adaptation Via Gamma Oscillations: the Case of Dystonia

GAMMA
Start date: February 2014
Phase: N/A
Study type: Interventional

Dystonia, a disabling disease with uncontrolled movement disorders was considered to be a manifestation of basal ganglia dysfunction, yet there is accumulating evidence from animal and human experiments that the cerebellum plays a prominent role in the pathophysiology of dystonia. Our recent results suggest a deficient cerebellar sensory encoding in dystonia, resulting in a decoupling of the motor component from the afferent information flow resulting from changes in the environment. An overall loss of gabaergic-mediated inhibition is at the forefront in dynamic changes in neural circuitry described in dystonia. In the mature brain gabaergic control the generation of temporal synchronies and oscillations in the glutamatergic neurons. Taken these all together with the results of a pilot experiment, the investigators hypothesize that deficient synchronies in the fast gamma range are one of the key mechanisms leading to abnormal communication inside the cerebello-cortical network in dystonia. The investigators aim first to demonstrate it by means of MEG (Magneto encepholography) recordings allowing to reconstruct the spatio-temporal dynamics of gamma oscillations in the nodes of the cerebello-cortical network. The investigators then aim to re-establish (if lost) or boost (if decreased) the defective synchronies by applying to the cerebellum at high gamma frequency a non invasive transcranial alternative current stimulation.

NCT ID: NCT01497639 Completed - Primary Dystonia Clinical Trials

Comparison of the Efficacy of Double Monopolar Versus Interleaving Stimulation Modes for Pallidal Deep Brain Stimulation

Start date: March 2012
Phase: N/A
Study type: Interventional

The aim of the study is to compare the efficacy and the safety profile of the newly introduced interleaving stimulation mode to those of the standard double monopolar stimulation mode during pallidal deep brain stimulation of primary generalized or segmental dystonia.

NCT ID: NCT01191307 Terminated - Epilepsy Clinical Trials

Assess Specific Kinds of Children Challenges for Neurologic Devices Study

Start date: March 2009
Phase: N/A
Study type: Observational

The ASK CHILDREN study is intended to aid in future development of various neurologic devices (i.e. neuroprostheses). The ASK CHILDREN study seeks to use study information obtained to identify more efficient strategies in the evaluation and review of neuroprostheses regulated by the Agency.

NCT ID: NCT01168388 Completed - Hemifacial Spasm Clinical Trials

Movement Disorder Survey in East China

MDS
Start date: April 2010
Phase: N/A
Study type: Observational

Movement disorder involve recurring or constant muscle contractions causing squeezing or twisting movement, such as hemifacial spasm, blepharospasm, cervical dystonias etc. The most common focal dystonia was cervical dystonia in western countries according to previous studies, which is different from China in Chinese neurologists' opinion. And there is no such survey. So the investigators are conducting a movement disorder survey in east China to confirm it.