Prevention of Post Operative Ileus Clinical Trial
Perioperative Celecoxib to promote bowel movement and to reduce post-operative pain after elective colonic resection.
Post-operative ileus is a common surgical complication occurring in with up to 20% of
patients, with a significant clinical and economical effect.
Many preventative measures have been tested to promote gastrointestinal motility following
intestinal surgery have been suggested.
The medical intervention in the proposed study includes administration of a selective COX-2
inhibitor, specifically Celecoxib, in the peri-operative period following an elective colon
resection. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with
anti-inflammatory, analgesic, and antipyretic therapeutic effects.
The drug is approved for use in by the ministry of health in Israel and in the United
states. The study aims to assess the use of this widely used medication for evaluation of
the clinical effect on post-operative bowel transit, as well as the drugs' effect on
post-operative pain.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention