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Clinical Trial Summary

The purpose of this study is to confirm hypothesis that Glibenclamide can be administered orally and is an alternative to insulin therapy in treating transient hyperglycemia of premature newborns.


Clinical Trial Description

Transient hyperglycemia of premature newborns results from an overall decrease in insulin sensitivity, which is responsible at the beta cell level for abnormalities of intragranular cleavage of proinsulin into insulin, leading to reduced active insulin secretion. Intravenous administration of exogenous insulin can be used to combat insulin resistance and lower blood glucose, but it is difficult to manage in premature newborns and is associated with a substantial risk of hypoglycemia. Glibenclamide, which stimulates endogenous insulin secretion and can be administered orally, might be an alternative to insulin therapy in treating transient hyperglycemia of premature newborns. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05687500
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Elsa KERMORVANT, Pr
Phone 01 71 19 61 75
Email elsa.kermorvant@aphp.fr
Status Recruiting
Phase Phase 2
Start date May 20, 2023
Completion date May 2026

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