Preterm Labor Clinical Trial
Official title:
The Use Of Intramuscular Hydroxyprogesterone Caproate For Management Of Placenta Previa Before 34 Weeks Of Gestation
Antepartum hemorrhage is defined as bleeding from or within the female genital tract,
occurring from 24+0 weeks of pregnancy and till delivery of the fetus. Antepartum hemorrhage
occurs in 3-5% of pregnancies and is an important cause of perinatal and maternal morbidity
and mortality worldwide.
Placenta previa is a placenta inserted wholly or in part into the lower segment of the
uterus. It is classified by ultrasound to Placenta previa major degree when the lower edge of
the placenta lies within 2 cm from the internal cervical os and Placenta previa minor degree
if the lower edge of the placenta at lower uterine segment but more than 2 cm from internal
os. Placenta previa is responsible for 0.03% of maternal mortality and 8.1% of perinatal
mortality of 8.1% in the developed world and much more in developing countries.
Many studies in literature proved the positive correlation between the Placenta previa and
preterm uterine contractility and also reported that large proportion of women who have
Placenta previa associated with vaginal bleeding will have subclinical uterine contractions
before the onset of evident vaginal bleeding.
There are many tocolytic agents may have a role in conservative management of Placenta previa
such as magnesium sulfate and β-sympathomimetics .Progesterone is essential for continuation
of pregnancy and helps in maintenance of pregnancy . Delaying delivery may reduce the fetal
morbidity by helping maturity of vital organs. In 2003 Meis et al. in a large randomized
placebo-controlled trial found a significant reduction in recurrent preterm birth before 37
weeks for women who received 17αHP-C versus a control group receiving placebo (36.3% versus
54.9%).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT06168149 -
The Relationship of Fetal Lung Elastography Values With the Development of Respiratory Distress in Cases of Preterm Labor
|
||
| Completed |
NCT02538718 -
Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor
|
N/A | |
| Not yet recruiting |
NCT05864066 -
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals
|
||
| Terminated |
NCT03715530 -
Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women
|
N/A | |
| Recruiting |
NCT03638037 -
Correlation Between Maternal Vitamin D Level And Preterm Birth
|
||
| Recruiting |
NCT03992534 -
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
|
Phase 1 | |
| Completed |
NCT02536352 -
Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being
|
Early Phase 1 | |
| Withdrawn |
NCT03122704 -
Group B Streptococcus (GBS) Infection and in Preterm Labor Women Conceived Through IVF
|
N/A | |
| Recruiting |
NCT01518816 -
Role of Serum Total Antioxidant Level in Preterm Labor
|
N/A | |
| Recruiting |
NCT04590677 -
Prediction of the Onset of Term and Preterm Labour
|
||
| Completed |
NCT03112018 -
Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda
|
N/A | |
| Active, not recruiting |
NCT04301518 -
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
|
N/A | |
| Completed |
NCT03785795 -
Multichannel EMG Diagnosing True Preterm Labor
|
||
| Withdrawn |
NCT02351310 -
Effectiveness of ACS in Extreme Preemies
|
Phase 3 | |
| Not yet recruiting |
NCT01985594 -
Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial
|
Phase 2 | |
| Not yet recruiting |
NCT04532086 -
Uterocervical Angle and Preterm Labour
|
||
| Completed |
NCT04605172 -
Lockdown Impact on Spontaneous Premature Birth in a Level III NICU
|
||
| Recruiting |
NCT04417595 -
Investigating N-3 Fatty Acids to Prevent Neonatal Tobacco-related outcomeS
|
Phase 2 | |
| Completed |
NCT03923023 -
Impact of the PREEMI Package on Neonatal Mortality
|
||
| Recruiting |
NCT06157203 -
Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients
|