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NCT03798964 Clinical Trial

The Expression Heparanase in Term and Preterm Placentas

Preterm Birth Clinical Trial

Official title:
The Expression Heparanase in Term and Preterm Placentas

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03798964
Other study ID # HYMC-0119-18
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 23, 2019
Est. completion date November 24, 2020

Study information
Verified date June 2022
Source Hillel Yaffe Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Heparanase is an endo-β-glucuronidase that cleaves heparin-sulfate (HS) side chains of heparan sulfate proteoglycans, an integral constituent of the extra cellular matrix (ECM). This study aims to investigate the association between heparanase expression in the human placenta and preterm birth (PTB) . The investigators hypothesize that an abnormal placentation causes relative placental ischemia that induces higher rates of heparanase expression.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date November 24, 2020
Est. primary completion date November 24, 2020
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: - Singleton pregnancy Exclusion Criteria: - High-risk patients - Multiple pregnancy - Significant maternal illness - Significant fetal anomaly

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Placental analysis
Analysis of placenta to determine expression of heparanase

Locations
Country Name City State
Israel Hille Yaffe Medical Center Hadera

Sponsors (1)
Lead Sponsor Collaborator
Hillel Yaffe Medical Center

Country where clinical trial is conducted

Israel, 

Outcome
Type Measure Description Time frame Safety issue
Primary Heparanase expression Heparanase expression in the human placenta following delivery will be evaluated by western blot analysis in the three groups and will be compared to determine differences in the levels. Six months
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