Preterm Birth Clinical Trial
Official title:
Preterm Birth and Long Term Consequences on Myocardial Functions and Structure
Cardiovascular diseases (hypertension, coronary heart disease, stroke and cardiac
insufficiency) are the leading cause of death worldwide. They are a major cause of concern in
public health worldwide as well. Their incidence is increasing especially in emerging
countries. It has been shown through epidemiological and experimental studies that these
cardiovascular diseases are influenced by environmental factors which can act early during
different periods of the development. Preterm birth is an emerging risk factor of
cardiovascular diseases. Preterm birth rate varies accordingly to countries from 6 % to 14 %
and accounts for 80% of low birth weight. These past thirty years have shown an improvement
in the management and survival rate of these babies. The number of preterm infants reaching
adulthood is thus increasing. Long term effects of preterm birth on cardiovascular diseases
are little known.
However, emerging evidence suggest that preterm birth affects certain functions and
structure. A significant increase in blood pressure and alterations on the vascular,
metabolic, and renal systems have been reported in healthy young adult born preterm. And
abnormal heart shape with left ventricular hypertrophy have been demonstrated in these
population (Oxford)
Cardiovascular diseases (hypertension, coronary heart disease, stroke and cardiac
insufficiency) are the leading cause of death worldwide. They are a major cause of concern in
public health worldwide as well. Their incidence is increasing especially in emerging
countries. It has been shown through epidemiological and experimental studies that these
cardiovascular diseases are influenced by environmental factors which can act early during
different periods of the development. Preterm birth is an emerging risk factor of
cardiovascular diseases. Preterm birth rate varies accordingly to countries from 6 % to 14 %
and accounts for 80% of low birth weight. These past thirty years have shown an improvement
in the management and survival rate of these babies. The number of preterm infants reaching
adulthood is thus increasing. Long term effects of preterm birth on cardiovascular diseases
are little known.
However, emerging evidence suggest that preterm birth affects certain functions and
structure. A significant increase in blood pressure and alterations on the vascular,
metabolic, and renal systems have been reported in healthy young adult born preterm. And
abnormal heart shape with left ventricular hypertrophy have been demonstrated in these
population (Oxford) The aims of this study are to evaluate the effects of preterm birth on
heart functions and in a cohort of healthy young adults born preterm. Early alterations could
be observed, before the onset of disease. This study will include 60 young adults aged from
18 to 30 years, 30 of them born preterm (Preterm group) and 30 born at term with normal birth
weight (Control group). The groups will be matched for age and gender and tobacco exposition.
Young adults born preterm who will be included in the study were born and followed-up in the
Neonatal Unit, APHM, in Marseille. Data from the Control adult born at term are well known
and available (Marseille DOHaD Study, D.Barker (University of Southampton, England) and
K.Thornburg (OHSU Portland, USA)).
This study addresses the mechanism underlying the association between cardiovascular diseases
and preterm birth, and aims to identify early predictive markers in order to guide long term
follow-up of these young adults. The results of this study will help to develop specific and
accurate diagnostic tools and to implement preventive nutritional or pharmacological
strategies.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05934318 -
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)
|
N/A | |
| Completed |
NCT05502510 -
Assessing the Effectiveness and Efficacy of the MyHealthyPregnancy Application
|
||
| Not yet recruiting |
NCT03418311 -
Cervical Pessary Treatment for Prevention of s PTB in Twin Pregnancies on Children`s Long-Term Outcome
|
N/A | |
| Not yet recruiting |
NCT03418012 -
Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB
|
N/A | |
| Completed |
NCT02993744 -
Maternal Inflammatory Parameters Within Routine Treatment With Betamethasone
|
N/A | |
| Active, not recruiting |
NCT02673216 -
Infection and Adverse Pregnancy Outcome
|
||
| Completed |
NCT01683565 -
Preemie Tots: A Pilot Study to Understand the Effects of Prematurity in Toddlerhood
|
Phase 4 | |
| Completed |
NCT01412931 -
Protein and Ultrasound Indicators of Preterm Birth
|
N/A | |
| Completed |
NCT01460576 -
Improving Prematurity-Related Respiratory Outcomes at Vanderbilt
|
N/A | |
| Completed |
NCT02606058 -
The Australian Placental Transfusion Study (APTS): Should Very Pre Term Babies Receive a Placental Blood Transfusion at Birth Via Deferring Cord Clamping Versus Standard Cord Clamping Procedures?
|
N/A | |
| Terminated |
NCT03715530 -
Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women
|
N/A | |
| Completed |
NCT00422526 -
Progesterone for Prevention of Preterm Birth in Women With Short Cervix: Randomized Controlled Trial
|
Phase 3 | |
| Enrolling by invitation |
NCT04251260 -
Effectiveness of Positioning in Preterm Neonates
|
N/A | |
| Completed |
NCT03668860 -
India Dexamethasone and Betamethasone
|
Phase 1 | |
| Recruiting |
NCT03638037 -
Correlation Between Maternal Vitamin D Level And Preterm Birth
|
||
| Completed |
NCT02225353 -
Efficacy Study of a Cervical Pessary Containing Progesterone for the Prevention of Preterm Delivery
|
Phase 2 | |
| Recruiting |
NCT03992534 -
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
|
Phase 1 | |
| Completed |
NCT03144141 -
Association Between EHG and Risk of Preterm Delivery in Women Hospitalized for Threatened Premature Delivery
|
N/A | |
| Completed |
NCT05210985 -
Examination of the Relationship Between Home Affordances With Development
|
||
| Completed |
NCT04021654 -
What is the Future of Vulnerable New-borns
|