PreTerm Birth Clinical Trial
Official title:
The Effect of Zinc, Beta-carotene, and Vitamin D3 Supplementation as Pro-inflammation Mediated Regulator in Preterm Delivery Through Placental Protein Adaptor MyD88 and TRIF, Transcription Factor NFkB, and Pro-inflammatory Cytokine IL-1β
This study is a controlled trial which compares the effect of zinc, beta-carotene, and Vitamin D3 supplementation in pregnant women which has preterm birth. The measured outcome is zinc, vitamin A, and 25(OH)D level in serum and placenta, MyD88, TRIF, NFκB, and IL-1β levels in placenta.
The research will be held in Cipto Mangunkusumo General and Budi Kemuliaan Hospital.
Each participant of each group will be given the medication of preterm birth hospital
protocol, which includes nifedipine 4x10 mg as tocolytic agent, dexamethasone 2x6 mg
intravenous for 2 days which aims to support lung maturation, and antibiotic. Then, the blood
sample is obtained for zinc, vitamin A and 25(OH)D levels examination. Subjects will be
divided into 2 groups which are group whose given the oral zinc 50 mg/day, oral beta-carotene
25,000 IU and oral vitamin D3 50,000 IU/week supplementation, and group who is not given the
intervention. Each participant will be observed until delivery. After delivery, level of
zinc, vitamin A, and 25(OH)D in serum and placenta will be measured, as well as level of
MyD88, TRIF, NFκB, and IL-1β in placenta.
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