Preterm Birth Clinical Trial
Official title:
Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy Without Prior Spontaneous Preterm Birth
Preterm birth (PTB) is a major cause of perinatal morbidity and mortality. Worldwide, about
15 million babies are born too soon every year, causing 1.1 million deaths, as well as short-
and long-term disability in countless survivors. Few prognostic tests are available to
predict PTB. A short transvaginal ultrasound cervical length (TVU CL) has been shown to be a
good predictor of PTB.Different strategies have been adopted for prevention of PTB. The
evidence supports the use of vaginal progesterone in singleton pregnancies with short cervix,
while cervical cerclage seems to be beneficial only in the subgroup of singleton gestations
with both prior spontaneous PTB and TVU CL ≤25mm, and not in singletons without prior PTB,
nor in multiple gestations.
However, so far there are no level-1 data on the efficacy of TVU CL screening neither in low
risk nor in high risk pregnancy Thus, we aim to assess the efficacy of a policy of TVU CL
screening in singleton pregnancy without prior spontaneous PTB
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